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Test Code : LOT-828
Test cognomen : Administering IBM Workplace Services Express 2.6
Vendor cognomen : IBM
: 86 existent Questions

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IBM Administering IBM Workplace Services

IBM's Pa. debacle: condition wants IBM to pay for $170 million paraphernalia that did not drudgery | killexams.com existent Questions and Pass4sure dumps

Pennsylvania's application to Get $one hundred seventy million in damages and costs lower back from IBM Corp. for a failed desktop paraphernalia survived its first leer at various ultimate month. A dozen introductory objections from IBM's manhattan and Harrisburg legal professionals absorb been denied via Dauphin County unbiased Pleas court choose Andrew H. Dowling on Nov. 21. He set target dates for discovery and depositions, with the tribulation set for 2020, barring further extend.

All that legal artillery will battle to Get to the bottom of an initial $one hundred ten million contract, signed with inordinate hopes in 2005 under Gov. Ed Rendell, that became hypothetical to live achieved by 2010. Or 2011, or 2012, under Gov. Tom Corbett, because the deal became amended and delays, bugs, and brought funds proliferated.

Or in no way, because it labored out.

Pennsylvania had its partake of previous assistance-know-how disasters in its emergency communications, welfare, and tax places of work, amongst others. The IBM lawsuit, filed by using Gov. Wolf's administration final spring, gives a window into how massive-ticket assistance-expertise contracts can grind on for years, drinking millions of taxpayer bucks, devoid of enhancing public functions.

The condition wishes IBM to pay for infraction of contract, fraudulent inducement, remiss misrepresentation, nondisclosure, and fraudulent concealment. IBM has called the case "devoid of merit." Its attorneys didn't reply to calls.

The IBM system was purported to tackle payroll deductions and unemployment compensation payments from nearly 300,000 Pennsylvania employers. starting within the Sixties, IBM and different contractors had helped the condition custom-build separate tax and compensation systems, in hopes of reducing labor charges and rushing construction.

by means of 2005, youngsters, the condition recognized it was saddled with an "inefficient," expensive, and handiest partly automatic legacy of "increasingly outdated, desktop methods," based on the suit. instead of up to date network processing, video-like interfaces and actual-time updates, Pennsylvania nevertheless used mainframe computer systems, eco-friendly-monitor terminals, and day-conclusion record-batching.

So the condition department of Labor and industry called on tech contractors to bid on customized-constructing a "complete, finished, built-in and totally functioning" unemployment compensation gadget, meeting 1,500 company requirements, to seamlessly substitute its "mission vital" services through 2010.

IBM pitched difficult: in line with the fade well with, the trade spoke of its long event with Pennsylvania, its deep pool of skilled application and administration talent, and "wide working talents and potential in the unemployment compensation field" would assure the job bought done reform and on time. In June 2006, the condition employed IBM.

however "regardless of being paid almost $a hundred and seventy million," $60 million over funds, and receiving time extensions beyond the customary contact, "IBM in no pass delivered," in response to the state.

"IBM had no expostulate of staffing the project as described," according to the lawsuit. while its salespeople were promising a thorough job, the business's Wall street-mindful administration became relocating forward with plans "to establish off thousands of U.S. personnel in covet of outsourcing drudgery to offshore contractors" or "more cost-effective overseas labor." dealing with a brand novel generation of tech rivals, IBM "decided that its partake charge necessary to seize priority over customer pride and proper venture start."

as an example, in keeping with the complaint: IBM sent a team of trade analysts to start the assignment in 2006. In 2008, with their design complete however not yet applied, the solid pulled them out, growing "an information gap" just as it changed into time to jot down software code and design functions.

soon after, IBM's "every day leads on the challenge" had been moved out. (One, Robert Donaldson, in 2011 grew to live IT chief for the Pennsylvania branch of income.) Untested code piled up. IBM blew previous time limits, then "tried to obscure and whitewash these data with deceptive, intentionally complicated stories."

In 2013, with the IBM assignment  "45 months in the back of agenda and $60 million over finances," the condition hired Carnegie Mellon's application Engineering Institute to audit the task. The faculty organize "an abnormally high cost of defects" in IBM's incomplete code. Carnegie Mellon advised in opposition t completing the software "on account of the elevated haphazard of failure." The condition canceled the IBM task and went back to its aged legacy programs.

Pennsylvania is rarely the best condition that claims IBM ripped it off. In 2010, Indiana sued IBM after canceling a condition welfare-processing contract. IBM sued back. A lessen court advised the condition to pay IBM $52 million in 2012. Two years later an appeals courtroom reversed that ruling and pointed out IBM owed Indiana at least $50 million. That case is noiseless in court.

To remain away from future application meltdowns, condition officials led by means of Sharon Minnich, the Deloitte Consulting and SAP veteran who heads Pennsylvania's office of Administration below Gov. Wolf', dispute they've taken steps to standardize and partly centralize condition application procurement and overview contracts with additional oversight.

they absorb got additionally hired a novel unemployment-compensation benefits-modernization contractor, Florida-primarily based Geographic solutions Inc.,a one hundred seventy-grownup, 25-12 months-historic deepest company with different condition clients. Geographic has agreed to supersede that gadget for $35 million, a fraction of what IBM charged. additional mission managers could add up to $10 million.

This time, the contractor expects to purchase solutions already used by using dozens of different states off the rack, as a substitute of pile novel ones. even if you credit the state's more advantageous management, or the application trade's evolution towards off-the-shelf (or downloaded) commodity items in the 12 years considering the fact that the IBM deal became signed, it appears as if taxpayers may additionally ultimately live in for an IT dividend.

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IBM Accused of Violating Federal Anti-Age Discrimination legislation | killexams.com existent Questions and Pass4sure dumps

The IBM logo on the entrance to the highlight Towers in Munich, Germany.

ProPublica is a nonprofit newsroom based mostly in novel york. check in for ProPublica's massive chronicle e-newsletter to receive reports enjoy this one for your inbox as soon as they're posted.

a group of former employees has filed a lawsuit in opposition t IBM that accuses the tech mountainous of failing to conform to a federal legislation that requires organizations to expose the ages of people they lay off who're forty or older. The swimsuit, filed in federal district court in manhattan city, additionally alleges that the enterprise has improperly prevented workers from combining to problem their ousters.

it is the second vast prison action in opposition t IBM due to the fact that a 2018 ProPublica chronicle that documented frequent age discrimination by the company in its international restructuring. the former personnel are asking the courtroom to invalidate a written settlement that IBM requires its employees to signal to Get hold of severance pay. beneath the document’s provisions, employees comply with hand over any appropriate to problem their dismissal in court docket.

before, most age-connected legal moves contesting an IBM layoff absorb been brought with the aid of the rare ex-employee who refused to note the condense and left with out severance. If the district courtroom were to conform that IBM’s separation condense is invalid, it may open the trade as much as lawsuits by using tens of heaps of older workers IBM has laid off in fresh years.

today’s lawsuit and the string of other instances filed in the wake of ProPublica’s chronicle puss precipitous odds on account of choices by the Supreme court docket and federal appeals courts that curtailed laborers’ capability to problem employers’ staffing selections. The rationale is to restrict what federal judges view as cumbersome, costly cases that hamstring both employers and the courts.

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“The Supreme court docket is antagonistic to category motion, to collective motion and to employees,” said Cliff Palefsky, a swank San Francisco legal professional who frequently represents personnel. “Congress must step in to retain the integrity of its own civil appropriate legal guidelines, now not simply involving age, however additionally race and gender. up to now, it hasn’t.”

ProPublica mentioned in March 2018 that IBM, which had annual profits of $79 billion final yr, had ousted an estimated 20,000 U.S. worker's a while forty and over everything over the preceding five years. In some instances, it used funds saved from the departures to employ green replacements to, within the phrases of 1 inner trade doc, “appropriate seniority combine.”

the brand novel lawsuit follows criminal action remaining drop by means of Boston category-motion legal professional Shannon Liss-Riordan, who filed a class-action case on behalf of 60 ex-IBM employees who had no longer signed the severance settlement and argued they had been discriminated in opposition t on account of their age. In tandem, Liss-Riordan filed rankings of arbitration claims for ex-personnel who had signed the document, which handiest makes it feasible for employees to pursue age claims in particular person arbitration hearings.

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The mountainous apple lawsuit opens a brand novel felony entrance, difficult the IBM contract’s one-at-a-time restrict as a violation of people’ rights below the federal Age Discrimination in Employment Act. The law permits laid-off people to seize prison action against their employers as a bunch, either in court docket or arbitration.

“IBM towards one person isn't a just fight,” said David Webbert, an Augusta, Maine, legal professional who, in conjunction with his accomplice, Jeffrey younger, and a Washington-based mostly legislation company, filed the brand novel case. “IBM towards thousands of individuals who’ve been laid off as a result of their age, that’s a legitimate prison proceeding.

“IBM is petrified of a ample fight,” Webbert spoke of.

A spokesman referred to the company had no comment on the newest lawsuit. in keeping with ProPublica’s introductory findings in 2018, IBM talked about: “we're gratified with their enterprise and their employees’ means to reinvent themselves term after period, whereas everything the time complying with the law. Their capacity to try this is why we're the most efficacious tech company that has no longer most efficacious survived but thrived for more than a hundred years.”

the novel suit is filed within the cognomen of four ex-employees who absorb been of their mid-50s once they had been ousted by the company, including Cheryl Witmer of Firestone, Colorado.

Witmer eminent in an interview she started her profession repairing IBM Selectric typewriters in 1984 and became a software supervisor in the business’s cloud division in 2016 when she abruptly received a foul job-efficiency ranking and become advised she become retiring.

“however I’m now not retiring,” she pointed out she instructed her manager.

“sure, you're,” she quoted the manager as replying. ProPublica documented dozens of similar employee ousters that began as layoffs however absorb been transformed to retirements, a transformation that saved down IBM’s layoff counts, where inordinate numbers can set off public disclosure requirements.

Witmer referred to she felt she had exiguous alternative but to note the enterprise’s severance settlement because she necessary the funds while she searched for a brand novel job. “I couldn’t find the money for no longer to” signal, she referred to.

examine extra chopping ‘historical Heads’ at IBM because it scrambled to compete in the web world, the once-dominant tech enterprise reduce tens of lots of U.S. worker's, hitting its most senior employees hardest and flouting rules in opposition t age bias.

The ADEA requires that workers over forty who're being laid off live informed the job positions and the a while of the dwelling holders who're being laid off with them so that they can settle even if to pursue an age-discrimination case or to waive the reform to achieve this.

IBM stopped providing this counsel to personnel in 2014 when it rewrote its severance agreement. under the used settlement, departing employees couldn't acquire severance until they agreed to waive their privilege to pursue legal motion. the novel agreement employees absorb been required to signal to acquire severance did enable them to file claims of discrimination, but best in individual hearings earlier than an arbitrator.

IBM executives seem to absorb concluded that this exchange in the doc accredited them to quit offering the ages of personnel absorb been being laid off. legal experts dispute this made it a ample deal tougher to find facts of age discrimination, which requires establishing a sample drawn from tremendous numbers of layoffs.

until the newly filed swimsuit, IBM’s conclusion to quit disclosing age assistance has no longer confronted felony problem.

it live 2019 and IBM remains trying to find a utilize Case for Blockchain | killexams.com existent Questions and Pass4sure dumps

IBM claims that six banks will challenge stablecoins the usage of its World Wire protocol which is according to the Stellar network. based on the tech colossal, three banks absorb publicly committed to the initiative, and the the rest will divulge themselves quickly. The announcement joins the resurgence of blockchain razzmatazz this yr that feels eerily similar to the closing time allotted ledger know-how (DLT) was the cat’s meow returned in 2016.

additionally study: Bitcoin’s companionable condense should live Resilient to the Whims of Future Generations

IBM’s Race to remain important: From the ‘biggest industrial makes utilize of of Blockchain’ to inner most Banks Issuing Stablecoins

With JP Morgan’s newly announced coin and Digital Asset replacing Blythe Masters with novel CEO Yuval Rooz, it looks blockchain hype is steaming up as soon as once more enjoy a warm pile of cow manure. One leading illustration is IBM currently making headlines when it announced that six banks signed letters of intent to supply stablecoins using the IBM protocol called World Wire. The shower of IBM’s irrational blockchain announcements over the years indicates the fervor with which the multinational tech solid has tried to continue to live principal. just a few individuals might recollect the disbursed ledger mania three years ago when IBM told the world it deliberate to launch “the largest commercial uses of blockchain” by pass of September 2016, returned when everyone became gaga for commercial enterprise blockchains that absorb produced nothing however media puffery.

despite the fact, in accordance with IBM’s vice president of blockchain technologies, Jerry Cuomo, and a slew of online publications, the system promised in 2016 become allegedly speculated to free one of the vital “$a hundred million in capital tied up at any given time in transaction disputes in the IBM global Financing unit.” IBM even released a blockchain platform available for cloud builders that seems enjoy a cheesy Javascript replica of the NXT blockchain with a unusual VS Code extension. IBM additionally everything started the Open Blockchain Initiative and worked with the Hyperledger project that 12 months. however just enjoy the storm of Hyperledger announcements, R3 signing 60 banks, and initiatives enjoy Citigroup’s ‘Citicoin,’ IBM’s greatest industrial makes utilize of of blockchain seem to live everything fluff. while public blockchains enjoy BCH, BTC, and ETH absorb settled trillions of notional charge in a permissionless manner they should noiseless doubtless ask: What absorb everything these company blockchains done in the eventual few years?

It's 2019 and IBM Is  noiseless Trying to Find a  utilize Case for BlockchainThe lackluster IBM Blockchain 2.0 beta platform. Media publications are sometimes desperate to file on these so-known as blockchains but rarely examine them and even leer on the protocol. Technobabble Blockchains With Zero Innovation

Now IBM is using the Stellar protocol and claims that the “IBM Blockchain World Wire permits economic institutions to pellucid and settle cross-border payments in seconds.” reading IBM’s World Wire homepage is enjoy having a horrible flashback to 2016, besides the fact that children, where it’s blockchain mania far and wide once more. The accustomed explanations cited for utilising IBM’s blockchain consist of lowering clearing expenses, low priced pass-border payments, and the ledger reduces loads of time. IBM’s website insinuates that unlike these loopy libertarian bitcoiners, the service provider is inclined to drudgery with the present pecuniary incumbents.

“Bitcoin mania has led some to believe that banks are no longer needed for restful international money switch — Banks, besides the fact that children, disagree,” explains IBM’s World Wire web page.

Of course, the commonplace population and even the media publishing IBM’s blockchain fluff pieces about their quest to comfy the globe’s cash transfer device most efficacious Get a gist of what the enterprise wants the public to see. As with most trade blockchain tasks, it’s everything closed door deals and the media receives a technobabble press free up about some banks the usage of the platform. no matter if it's IBM, Hyperledger, R3, or JPM coin, there’s nothing absorbing about these trade blockchain options. Yet they read about these vacuous initiatives daily in one of the most well-known crypto and economic word outlets.

It's 2019 and IBM Is  noiseless Trying to Find a  utilize Case for Blockchain

many of the projects are downright absurd, enjoy when every person acquired excited about Bumble Bee tuna products being demonstrated on the blockchain. private blockchain swaps and monetary banks buying and selling stablecoins add nothing novel to the table: achieve away with the flamboyant wrapped DLT packaging and everything you’re left with is a frequent database. Cryptocurrency imply Andreas Antonopoulos composed a tweet in 2016 that encapsulated the blockchain hype at the time.

‘fundamental banks comprehensive first international transaction the usage of a blockchain’ — You mean, the identical component bitcoin has finished a number of million instances?” Antonopoulos mocked.

The bitcoin evangelist continued:

Correction: Banks paid consultants lots to achieve once what bitcoin does for pennies each day, hundreds of instances, enhanced.

presently there are lots of projects that are permissionless and absorb an open ledger for everything and sundry to assess. simply because a blockchain project is backed by using ordinary massive identify incumbents doesn’t supply it an edge over public cryptocurrency systems that absorb been around for a decade. The DLT-embellished studies mountainous tech organizations enjoy IBM and banks enjoy JP Morgan churn out are exiguous more than a feeble try to remain crucial.

What achieve you suppose about IBM’s blockchain attempts over the years and other smartly known companies developing enterprise digital ledgers? let us know within the comments fragment below.

OP-ed disclaimer: here is an Op-ed article. The opinions expressed listed here are the author’s own. Bitcoin.com isn't liable for or amenable for any content, accuracy or fine inside the Op-ed article. Readers should noiseless achieve their personal due diligence earlier than taking any actions involving the content material. Bitcoin.com is not dependable, directly or ultimately, for any twinge or loss brought about or purported to live brought about by pass of or in reference to the utilize of or reliance on any tips in this Op-ed article.

graphic credits: Shutterstock, Twitter, IBM Cloud, and IBM logos.

At Bitcoin.com there’s a bunch of free useful functions. as an example, absorb you ever viewed their tools web page? You can even lookup the trade cost for a transaction in the past. Or compute the value of your latest holdings. Or create a paper pockets. And much more.

Tags in this taleAndreas Antonopoulos, Blockchain, Blockchain Hype, Bumble Bee Tuna, allotted Ledger technology, DLT, embellished experiences, Hyperledger, IBM, IBM’s blockchain, JPM Coin, N-Featured, inner most Blockchain, Puff Media, R3, Stellar, World Wire Jamie Redman

Jamie Redman is a monetary tech journalist living in Florida. Redman has been an active member of the cryptocurrency group considering that 2011. He has a keenness for Bitcoin, open supply code, and decentralized purposes. Redman has written thousands of articles for information.Bitcoin.com about the disruptive protocols rising nowadays.

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How A.I. Is Finding novel Cures in used Drugs | killexams.com existent questions and Pass4sure dumps

In the elegant silent of the café at the Church of Sweden, a narrow Gothic-style pile in Midtown Manhattan, Daniel Cohen is taking a demolish from explaining genetics. He moves toward the creaky piano positioned near the front door, sits down, and plays a flowing, flawless rendition of “Over the Rainbow.”

If human biology is the scientific equivalent of a complicated score, Cohen has learned how to navigate it enjoy a virtuoso. Cohen was the driving obligate behind Généthon, the French laboratory that in December 1993 produced the first-ever “map” of the human genome. He essentially introduced mountainous Data and automation to the study of genomics, as he and his team demonstrated for the first time that it was feasible to utilize super-fast computing to hurry up the processing of DNA samples.

Scientists worldwide absorb built on Cohen’s insights, and Cohen himself, an MD with a Ph.D. in immunology, has gone on to success as a researcher and pharma executive. But a quarter-century later, genomics has yielded few of the kinds of paradigm-changing medical breakthroughs that many of its early innovators hoped for. Today, as chief executive and founder of Paris-based drug startup Pharnext, Cohen is striving to understand why that rainbow hasn’t led to a pot of gold.

“Any protein in the corpse has many different functions, not only one,” he says, returning from the piano to talk with me, “just as you are a person who has many functions in the population, not just one.” The phenomenon Cohen is describing is “pleiotropy,” the capacity of a separate gene to absorb multiple, seemingly unrelated effects. It is one of the complexities of disease that has repeatedly frustrated medical researchers in their quest for therapies for the most stubborn illnesses.

Cohen not only appreciates pleiotropy’s significance: He believes that Pharnext and other drugmakers may soon exploit it—with a powerful boost from synthetic intelligence. By embracing the body’s complexity, and by using A.I. to more methodically analyze and map the pass the chain reactions of disease sweep through the body, he hopes to develop combinations of drugs tuned to assault a plethora of medical conditions.

Cohen and his team are moreover applying A.I. to search for therapies that leverage “repurposing”—combining existing drugs in ways that give them therapeutic powers that each lacks in isolation. Their long-term goal is a drug pipeline that is far more efficient than mountainous Pharma’s notoriously gradual R&D departments—streamlined by machine learning. Cohen’s sleepy peer widens with enthusiasm when he describes how it’s everything coming along. “Très bien,” he says. “Très économique.”

Running in the identical race as Pharnext are companies ranging from giants enjoy Google and IBM to startups such as Insilico Medicine, Recursion Pharmaceuticals, and BenevolentAI. everything are deeply invested in the tools of A.I., using them to analyze millions of examples of drug and patient data and tease out patterns of significance. But Pharnext, founded in 2007, predates most of those competitors by several years—and has a longer head start when one factors in Cohen’s decades of earlier research in genomics and pleiotropy.

And perhaps most important, Pharnext’s application of A.I. to medical problems over the course of more than a decade has finally reached a captious inflection point. In October, Pharnext reported positive results for a aspect III tribulation in humans of one of its drug combinations. The compound is PXT3003, a treatment for a neurodegenerative condition called Charcot-Marie-Tooth disease (CMT), a rare disorder for which no remedy has been found. The primary cause of CMT is duplication of a separate gene, but a all cascade of vitiate things ensues “downstream” from that mutation. Schwann cells, which protect nerves, regress into stem cells that don’t achieve their job. Axons in the nerves open to die off. Muscles can’t live controlled, and they shrink as a consequence.

According to Pharnext, its aspect III results (which absorb not yet been peer-reviewed) showed CMT not merely stabilizing under PXT3003 but moreover being reversed, as cells began regenerating. Previous treatments, Cohen says, had managed only to gradual patients’ decline. Under PXT3003, patients showed statistically significant improvement on two measures of disability. Based on those results, in February the U.S. Food and Drug Administration granted Pharnext “fast track” status for that therapy—an accelerated review process, awarded only when the agency thinks a drug demonstrates “superior effectiveness” in treating a earnest disease.

View photos

PATHWAYS: To advocate find therapies, A.I.-driven startups build maps that point to how genes, proteins, and the corpse interact as diseases progress. This illustration depicts Pharnext’s map for CMT, a neurodegenerative condition.


It is, to live sure, only one hopeful step against one rare ailment. Still, technology has shortened Pharnext’s path in ways with promising long-term implications, shaving years off the drug-design timeline. Preclinical testing and clinical trials generally seize eight to 10 years, and developing a novel drug completely from scratch can add seven years to the process, sometimes much more. In the case of PXT3003, in contrast, A.I. helped Pharnext select three existing drugs to repurpose: baclofen, a muscle relaxant; naltrexone, used to treat opioid dependence; and sorbitol, a glucose reduction used as a laxative. Because the drugs were already in use, Pharnext could skip the aspect I trials normally required to ensure their safety—and purge the “build from scratch” stage.

FDA fast-tracking increases the odds that PXT3003 could live on the market as soon as 2020—and it’s only one of Pharnext’s many projects. The company will soon open a second aspect II tribulation of a drug with indications for Alzheimer’s and a first aspect II tribulation for an ALS therapy, in both cases using a similar repurposed combination.

Just as important: If these experiments succeed, copycats with deeper pockets could succeed suit. Kathleen Sebelius, a secretary of Health and Human Services in the Obama administration who is now a consultant and board member for several health custody companies, sees the efforts as fragment of a growing trend to repurpose. “That everything leads to the possibility of a lot shorter investment cycle, and potentially a very different pricing point, and lots of possibilities for rare diseases where there just hasn’t been enough of a pecuniary incentive,” she says. “And that has lots of appeal.” Eric Kandel of the Kavli Institute for Brain Science at Columbia University, a winner of the Nobel Prize in physiology or medicine who is an adviser to Pharnext, says that the startup is at the leading edge of the trend, calling its methodology “both original and powerful.” As for whether that approach will snare on widely, Kandel adds, “We should know soon.”

At the dawn of modern genetic research, almost no one anticipated the gigantic complexity in the biology of disease. Many researchers thought the genome would live a benevolent of instruction manual for the body. Pioneers such as Celera Genomics’ Craig Venter and Francis Collins of the National Institutes of Health were celebrated as “gene hunters,” a term that evoked crusaders scouring the globe for that one “silver bullet” gene that would explain—and facilitate a remedy for—a given disease.

To some extent, these researchers organize existent treasure. Geneticist Nancy Wexler, for example, spent years in Venezuela compiling family trees of those affected by Huntington’s disease, a rare, inherited condition. Her drudgery led to the discovery of the mutation in a separate gene that predicts whether an individual will condense the condition.

But scientists soon realized that genetic maps were less enjoy an instruction manual and more enjoy the parts catalog you Get with Ikea furniture. What’s more, researchers discovered other catalogs that added complex variables to the relationships between genes and disease—for example, the proteome, the proteins encoded by DNA, and the transcriptome, everything the nucleic acids that transmute DNA into proteins.

The morning-after disappointment has proved wrenching, as researchers learned that complex diseases, such as cancer and Alzheimer’s, didn’t submit to a separate gene. (Even Huntington’s, its gene identified, has remained untreatable.) Today, Cohen and others observe a link between the obsession with simplicity and a decline in drug discovery. That decline shows itself in the 1-in-10 success rate for FDA approval of novel therapies; in spiraling costs for drug development (what a Tufts study recently identified as “the $2.6 billion pill”); and in the soaring prices of the few treatments that demolish novel ground, such as the $475,000 cost of a course of treatment with Novartis’s leukemia drug Kymriah.

More recently, researchers absorb begun to grapple with biological complexity with the advocate of the science of networks. That science’s chief evangelist is Albert-László Barabási, a professor at Northeastern University whose 2014 engage Linked popularized the notion that network theory can define numerous fields, from vogue trends to sexual relations to disease. Barabási and others realized that disease is enjoy a vitiate signal that moves through a network of connections from genes to proteins to cells to tissues, until everything these “perturbations” manifest as the close symptoms of disease.

View photos

Ads posted in the Paris Metro as fragment of a public-awareness campaign about CMT. CMT advocates dispute the disease affects about 1 person in 2,500 worldwide.


Complicated diseases are confluences of numerous effects, because pleiotropy means that any given protein can act at different points in the body. Startups enjoy Pharnext assume that drugs can moreover live pleiotropic, acting on more than one protein and more than one interaction in the corpse at the identical time. To find a drug combination capable of tackling complexity, the gigantic power of machine learning, with its capacity to spot patterns in data, must live wedded to a sense of the structure by which disease operates.

This, in turn, has required an evolution in the relationship between computer scientists and biologists. Newer machine-­learning approaches ingest vastly more data and can assemble hierarchies of information that let them fade beyond correlation. Still, harnessing these “deep learning” neural networks into a structure that has any predictive power requires some elegant algorithm-building.

Colin Hill, CEO and founder of GNS Healthcare, is one of the builders. His company, based in Cambridge, Mass., has spent 18 years developing a computer system called REFS, which stands for “reverse engineering, forward simulation.” GNS has raised a total of $38 million over the years—from Amgen Ventures, the venture capital arm of the drug giant, along with Celgene and a variety of other investors—to build and fine-tune its models of disease. And in a recent sequence of trials, first published in 2017 in the medical journal The Lancet, GNS has particular REFS’s potential when applied to a disease such as Parkinson’s—an ailment in which pleiotropic factors render existing treatments wildly hit-or-miss in their effectiveness.

With Parkinson’s, the network of interactions set in motion by defective genes has a particular shape to it, and the breakdown of motor functioning is the most reliable indication of its progression. Feeding the genetic data of Parkinson’s sufferers and a control group into REFS helped GNS generate over 100 computer models depicting what might live going on as motor role deteriorates. The models can uncover previously unknown genetic mutations that may contribute to the speedup of deterioration.

View photos

But that’s just the first part. GNS has used those findings to create 5,000 different computer simulations of randomized control trials, each aiming to foretell how speedy the disease would progress with varying approaches to treatment. Such speed-­testing can live vastly more economical than seeking the identical result through controlled human trials. And GNS, in partnership with other drugmakers, is now applying similar approaches to treatments for diabetes, ALS, multiple myeloma, and breast cancer, among other diseases.

“We now absorb the capacity to create and construct, on the computer, representations of human patients and their diseases such that they can now probe, drug by drug, custody management intervention by custody management intervention, and dispute what treatments drudgery for which patient,” says Colin Hill, CEO of GNS.

The simulation, in other words, is not just finding correlations: It is answering What if questions. What if they had given drug A instead of drug B to patient X? That capacity to simulate and retort counterfactuals is a recent arrival in the practice of A.I. It owes its growing import in great fragment to GNS’s technology adviser, Judea Pearl, a longtime A.I. researcher and professor of computer science at UCLA. In a Popular volume published eventual year called The engage of Why, Pearl describes how legal intelligence ascends from merely noticing patterns, which machine learning does in spades, to being able to express counterfactual reasoning about what would absorb happened, based on those patterns. Data alone, disconnected from any concept of a mechanism, doesn’t provide existent insight. “Data is profoundly mute about causality,” claims Pearl. Hill puts it more bluntly: “Deep learning is not that deep.”

Daniel Cohen, now 67, spent his childhood in Tunisia’s heterogeneous society of Jews, Christians, Muslims, “living everything together in a very elegant and pacific way.” He credits that undergo for his tang for “things that are not complicated, but complex.” When he was 9, Cohen’s family immigrated to Paris, where he pursued the piano avidly. He switched to medicine once he realized he might absorb a greater impact as a scientist than a musician, but the passion has not left him. He has been a guest conductor at the Royal Philharmonic in London and dreams of leading that ensemble in Tchaikovsky’s Symphony Pathétique. “The predisposition to orchestra conductor, CEO, and scientist are everything controlled by the identical genes,” he jokes.

Parlaying genomics and technology into pharmaceutical success is something Cohen has done before. He was a cofounder of Millennium Pharmaceuticals, a U.S. oncology-drug maker that helped develop the multiple-myeloma treatment Velcade.

Cohen is bullish that Pharnext can live successful with A.I., but he is moreover alert of the technology’s limitations. Google’s ­AlphaZero, an A.I. program, was able to beat the world’s human masters at the Chinese strategy game Go, without using any prior human knowledge. But as Cohen points out, fade has a finite set of rules, which AlphaZero knew completely. In biology, thanks in fragment to pleiotropy, the rules are not fully known—and may never be.

View photos

But thoughtfully designed A.I. has enabled Pharnext to build models around the rules that are known and compose choices accordingly. Out of the universe of 10,000 known drugs, the company’s discovery model takes in an assortment of 2,000 that are both out of patent and “marketed”—that is, already judged both therapeutically efficacious and safe enough to live sold to the public.

To develop its CMT drug, Pharnext first spent about a year assembling its network model for the disease—a framework comparable to GNS’s Parkinson’s map, showing how nervous and sinewy problems “cascade” from the germane gene mutation. Based on this mechanism, the computer model arrived at a short list of 57 candidate drugs that addressed various points in the cascade. Pharnext tested those drugs one by one in vitro, generating a shorter list of 22 to live tested in mice, which finally yielded the three-drug combination that went to human clinical trials. The recent positive aspect III results confirmed that the PXT3003 cocktail is acting at various points in the cascade.

Without the A.I. model, many more years of preclinical testing would absorb been required beyond the three years it took Pharnext, says Cohen. “With 2,000 drugs [to start with], I could produce everything feasible combinations, a billion possibilities” to test in vitro. That’s a recipe for countless fallacious positives and departed ends—years of frustration, for now forestalled.

Pharnext’s shares, which trade on the Paris stock exchange, absorb more than doubled since October’s aspect III results announcement. The company has spent about 120 million euros ($135 million) over the past decade on research and development—a very modest figure by pharma standards. It has never made a profit, but analysts appraise that if PXT3003 reaches the market, revenue—9 million euros in 2018—could soar starting in 2020. (GNS Healthcare is privately held and does not disclose spending or revenue.)

Beyond feasible victories for investors, the advances at Pharnext and GNS point the pass to A.I.’s growing up—and pharmacology along with it. The capacity to intuition about causality, and to explore counterfactual questions, is a threshold that users of synthetic intelligence absorb long sought to cross. The computer models at these startups are making a foray in that direction as they manage and tame a bewildering number of variables.

Even the underlying definition of disease may evolve. As scientists are learning, these definitions absorb been overly simplistic. A study in the journal Bioinformatics eventual year eminent that attempts to treat tumors are hampered by the fact that genetic mutations in cancer are “fundamentally heterogeneous”: What appears as one disease, or class of disease, in fact contains few commonalities and many differences from patient to patient. As it becomes pellucid that what’s happening in any corpse differs sharply from the “on/off” model of one gene turning on a set of symptoms, technology can advocate drug developers wrestle with the complexity.

Last, but hardly least, these A.I.-driven efforts tender a glimmer of economic hope. In an era in which the cost of drug development is a daunting obstacle, smart algorithms may someday enable medical stakeholders to derive more value from the trillions of dollars that absorb already been spent on drug research. In theory, with repurposing, “you don’t necessity to design [new] drugs,” Cohen avers. “My passion is that with 50 drugs, they can treat everything.” That would spell changing yet another definition: the meaning of “discovery.”

A version of this article appears in the April 2019 issue of Fortune with the headline “Finding novel Cures in used Drugs.”

Hicham Oudghiri and Marc DaCosta: Data's cartographers | killexams.com existent questions and Pass4sure dumps

How much did the federal government shutdown cost? After 35 days of deadlock, $6,354,845,148 in wages had gone unpaid to 747,573 federal employees. Every second that ticked by added $2,118 to the figure. Some staffers were furloughed; many more worked without pay. At the Department of Homeland Security, for example, some 245,405 employees were unpaid and 32,706 furloughed. At Treasury, 36,309 workers were furloughed and 82,336 worked unpaid. At the Environmental Protection Agency, 52 percent of its staffers worked without compensation.

Getting a wield on the magnitude of this disruption—as well as its granular details—was no petite feat. A little-known novel York City fintech company named Enigma tabulated the rising costs in existent time on a website it threw up called Government Shutdown 2018–2019.

In order to achieve so, Enigma searched the Office of Management & Budget’s contingency plans for 109 federal departments. It moreover tapped FederalPay.org for unbiased salaries and worker counts for 46 agencies. In all, it combed through 2,000 pages and 2 million spreadsheet rows of federal data to create the tracker. From concept to launch, the application took three Enigma number crunchers a total of 36 hours.

The shutdown data is available free, but Enigma’s capacity to rapidly compose sense of multiple disconnected data ­sources, public and private, and create a customisable view of the global economy has attracted some of the world’s leading companies, from BlackRock to PayPal and Celgene, with many clients paying more than $1 million a year for fingertip access to its insights. 

Enigma is the brainchild of Hicham Oudghiri and Marc DaCosta, best friends since they met 16 years ago as undergraduates at Columbia University, where they studied philosophy. Their startup organises information from thousands of sources around the world into a single, fully linked interface.“People know how the internet works and how to log users and serve them cookies to imply products on Amazon. That problem is solved. What we’re doing is pile a model of the existent world,” says Oudghiri, 34, speaking from Enigma’s Humboldt boardroom, named after the Enlightenment-era Prussian philosopher. His co-founder, DaCosta, 34, adds, “This isn’t just about a faster microprocessor or better statistics. Enigma is a scholarship graph of what’s going on in the economy.”

Oudghiri and DaCosta’s journey into the domain of data mining began after the pecuniary pass of 2008. DaCosta was doing graduate drudgery in the cultural anthropology of data at the University of California, Irvine, while Oudghiri was managing renewable-energy projects for BCME Bank in Casablanca, Morocco. Both were curious about explaining the world in light of the global disruptions going on. So they reunited and began to organise sets of publicly available data, starting with Federal Aviation Administration flight logs. They soon discovered a trove of valuable information hiding in simple sight—buried in government logs, university research publications, arcane trade filings and shipping manifests. If they could collect, scrub, organise and analyse it, they thought, it might produce a near real-time rendering of the macro economy.

In 2011, Oudghiri and DaCosta formed Enigma and went to drudgery amalgamating public data, mostly from government ­sources enjoy the Census Bureau, the FCC, the Federal Election Commission and the IRS, as well as import records from the US Customs & brink Protection agency and pile permits, and putting it together as a separate source. They moreover became experts in uncovering complex, hard-to-find information. For instance, using freedom of Information Act requests, Enigma taps the CBP’s Automated Manifest System to track every container ship that arrives in the US, including the importer and port of call. From the National Fire Incident Reporting System, Enigma retrieves the cause and location of every fire in the US. To cover energy, Enigma leans on oil-well data from the Railroad Commission of Texas, founded in 1891 to establish tariffs.

The firm’s breakthrough year was 2014, when Enigma raised $4.5 million from Comcast, American Express and the novel York Times Co and entered the Fintech Innovation Lab, created by Accenture and the Partnership Fund for novel York City. There, embedded with banks and Wall Street giants, Oudghiri and DaCosta discovered that their data had immense utility in pecuniary services. Its information could live connected with customer data in banks’ systems, helping them more quickly recognise fraud or businesses and individuals to underwrite. “We walked out with a battle plan,” DaCosta says of the accelerator. They quickly built a software package, complete with colourful scholarship graphs, and establish specialised tools into a compliance interface they called Dossier.

To date, Enigma has synthesised 100,000 data sets in more than 100 countries, organised intelligence on 30 million petite businesses and accumulated 140 billion points of data on the US population. It has mapped every molecule used by the US pharmaceutical industry, as well as everything trials, patent filings and adverse events.

Braininess permeates Enigma’s headquarters in novel York’s Flatiron District: Conference rooms are named after philosophers enjoy Michel de Montaigne and Augustine. Bookshelves are filled with scholarly tomes, from coding manuals enjoy Machine Learning for Hackers and Data character and Record Linkage Techniques to classics enjoy the Dialogues of Plato, Ulysses and Rousseau’s Confessions. Covering the walls are maps and experimental artwork exploring “the intersection of data and experience”.

But Enigma’s nerdy academic culture hasn’t stopped it from attracting corporate clients and funding from Silicon Valley and Wall Street. BlackRock, PayPal, American Express, MetLife, BB&T, Celgene, Merck and EMD Millipore absorb signed up. Some $130 million in capital has flowed into the solid in the past seven years from venture investors enjoy NEA, Crosslink Capital and Glynn Capital and hedge funds enjoy Two Sigma Ventures and Third Point Ventures.

Forbes estimates Enigma’s valuation is $750 million, with revenues pushing $30 million annually, the company having doubled its customer foundation in 2018.

If a hedge fund wants to know which restaurant chains are growing the fastest, Enigma can check FCC logs for radio licences, which are required to open drive-through windows. Insurers utilize Enigma for risk assessment, and pharma companies query its data-crunching machines to ameliorate drug safety.

Want to quickly and precisely identify the best candidates for petite trade loans? Instead of cold-calling storefronts or schmoozing local Chamber of Commerce officials, Enigma will synthesise property-tax filing information with condition trade filings and Uniform Commercial Code liens to approach up with automated credit identities. necessity to avoid underwriting in risky fire zones? Why not sew together data sets on emergency-call logs and pile permits?

At MetLife, chief digital officer Greg Baxter is starting to utilize Enigma data pulled from public health systems and universities by connecting it to its own systems to detect pockets of illness or risk and to ameliorate underwriting. And in MetLife’s $588 billion investment management arm, Baxter is using Enigma data to quantify how the character of restaurants, parks and community event spaces affects existent estate prices. “They discover data sources, they organise the data and then they find ways through machine learning of connecting the data,” Baxter says. “When you combine that external data with their internal domain data, then you start to Get phenomenally predictive and insightful trends.”

Investor John Fogelsong of Glynn Capital thinks the startup could present a threat to legacy closed-system “big box” technology vendors enjoy Oracle, IBM, SAS and SAP: “Each novel data set Enigma ingests compounds the company’s capacity to ameliorate a customer’s trade processes.”BlackRock’s recent undergo is illustrative. When outspoken Cooper, its newly minted chief marketing officer, was asked to quake up how the $6-trillion-in-assets solid prospects for clients, Enigma made a surprising discovery: ornery to the traditional approach based on regional and demographic targeting, there was exiguous correlation between a client’s location and his or her preparedness for retirement, but political engagement ranked high. “If someone is politically active and even if they are a renter, they’re much more likely to map for retirement,” Cooper says. “It was shocking for us.” Not everything of Enigma’s machine-learning algorithms are trained on the seared pursuit of profits. The solid has volunteered its data efforts toward studying the gender gap across 558 occupations and has already identified that some of the most egregious disparities occur in accounting, retail and sales.After a November 2014 fire killed five people in a smoke-detector-less home in novel Orleans, Enigma worked with the city’s fire department and Office of Performance & Accountability to identify areas where fire safety is weakest.

On Enigma’s public website, it offers national fire-incident data free for city planners to use, and 50 years of weather anomalies in the US, plus nationwide data sets on everything from cancer statistics to so-called adverse events, as defined by the FDA. In novel York City, for example, an Enigma FOIA allowed it to synthesise years of rail incident and injury data reported to the Metropolitan Transportation Authority. The solid is moreover working with a non-profit called Polaris to combat and preclude slavery and human trafficking. The concept is that data can not only lead to better underwriting but moreover ameliorate government. Oudghiri and DaCosta call it “data for companionable good”.

Is Enigma vulnerable to the benevolent of data-usage scandals that absorb plagued Facebook?

“I assume the behaviour from the internet companies has been suspicious if not malicious, creating a picture of your behaviour that is probably above and beyond what you would consent to,” Oudghiri says, arguing that Enigma’s drudgery with pecuniary services firms strikes a more mutually beneficial covenant.

“Your data is a means to understand if you are a legitimate person,” he says. “From a privacy standpoint, you enter those relationships knowingly and explicitly. The necessity for sharing data arises from a pretty ample place.”

(This chronicle appears in the 12 April, 2019 issue of Forbes India. You can buy their tablet version from Magzter.com. To visit their Archives, click here.)

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IBM stock tumbles as year-over-year revenue declines for 20th consecutive quarter | killexams.com existent questions and Pass4sure dumps

In the first quarter, strategic imperatives revenue grew 12 percent to $7.8 billion, not adjusted for currency, while cloud revenue grew 33 percent to $3.5 billion. Net income was $2.3 billion.

Still, trade is likely to pick up in the second half of this year, as the company wraps up eventual year's acquisitions, releases novel products, closes on great contracts, and moves toward trade with better profit margins, executives said on a conference call.

"From my perspective, the quarter played out pretty much how I expected, other than they thought they had a couple more signings relationships in Services that they could absorb gotten done," Schroeter said in the conference call. "You absorb to ramp investment ahead of the revenue in order to Get that system ready, and that's the term we're in now, and we'll live in through the first half....we moreover absorb a lot of opportunities to realize efficiencies in how they run."

IBM's cognitive computing technology, Watson, continued to gain ground over the quarter, with novel features for marketing. The company moreover implemented machine learning into pharmaceutical research, and its property, The Weather Company, announced a novel collaboration with Samsung and Lyft.

"The legacy core is a trade that we're constantly reinventing," Schroeter said in the conference call.

During the quarter, "cognitive solutions" revenue grew more than 2 percent to $4.1 billion, not adjusted for currency, slightly above the $4 billion predicted by StreetAccount. Revenue from trade services and consulting fell slightly, in line with StreetAccount estimates, while sales from items enjoy infrastructure, hardware and operating systems fell slightly short of expectations.

Big Blue has moreover shifted its hiring focus, amid pressure from the novel U.S. presidential administration to hire more Americans. Under Rometty, IBM has pledged to hire about 25,000 U.S. workers in the next four years, including 6,000 in 2017. Many of those are expected to live "new collar" jobs, or jobs that focus on qualifications enjoy apprenticeships rather than traditional higher education.

At least one mountainous investor has pledged his loyalty to the brand: Berkshire Hathaway's Warren Buffett, who has praised IBM's dividends. Berkshire paid an unbiased charge of $170.43 per partake of mountainous Blue, as of January. IBM briefly traded above $171 on Tuesday during the regular session, but fell below $164 a partake after hours.

IBM said it returned $2.6 billion to shareholders through dividends and partake repurchases in the first quarter.

"Now the timing is right, is to Get the returns for their investments. If you were to poll 100 IBM executives, it's something that they'd everything say, now it's time to Get the returns," Schroeter said in the conference call. "We absorb driven very ponderous investment. That has impacted their margins... So yes, it is time for us to Get the returns. They absorb invested quite heavily. The strategy is right. They hear it from their clients every day. The places that they are piteous them to and the drudgery they achieve in the core is highly, highly valuable to them. So I assume now, to shorthand that, is yes. Now it's time."

Watch: IBM CFO on H-1B visa program

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