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920-130 Symposium Express call Center

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920-130 exam Dumps Source : Symposium Express call Center

Test Code : 920-130
Test denomination : Symposium Express call Center
Vendor denomination : Nortel
: 57 actual Questions

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Nortel Nortel Symposium Express Call

VoIP certification tracks - Nortel's assuage certifications | killexams.com actual Questions and Pass4sure dumps

As outlined in a outdated tip, corporations are enforcing IP telephony extra generally on their statistics infrastructures. The multiplied deployment has created a need for certified IP telephony engineers to deliver confirmed, most efficient-of-breed know-how.

The IP telephony certifications Nortel presently offers are divided into 4 categories: back specialist, Design specialist, steer expert, and Design expert. This tip discusses the Nortel aid song.

aid specialist

The aid professional certifications are intended to pomp someone's capacity to enforce, operate, and troubleshoot a Nortel Networks IP Telephony solution. The assuage specialist certification displays a candidate with three to six months of journey that may address pursuits technical concerns of a typical Nortel IP Telephony answer.

NNCSS - VoIP Succession BCM 3.0

This certification exams the capacity to implement, operate, and troubleshoot the company Communications supervisor 3.0. This certification covers hardware, delivery-up, statistics and voice networking, applications, and troubleshooting the BCM. To pass the certification, two assessments believe to exist efficiently accomplished: know-how standards and Protocols for IP Telephony solutions, and Succession BCM three.0. The know-how requisites and Protocols for IP Telephony options exam is an overview of convergence applied sciences.

NNCSS - CallPilot Rls. 2.0

This certification tests the means to reserve in force, operate, and troubleshoot the VoIP CallPilot 2.0. This certification covers hardware, administration, interoperability with Meridian 1 switches, and protection of a sole site CallPilot gadget. To whisk the certification, two checks must exist efficiently completed: Meridian Database and CallPilot 2.0.

NNCSS - Symposium denomination middle Server or Symposium call core Server installing and maintenance

These two certifications recognize at various the skill to reserve in force, operate, and troubleshoot the Symposium call middle Server. both certifications cowl hardware, application setting up, administration, and protection of Symposium denomination middle Server four.2, Symposium net client four.0, and Symposium categorical 3.0. although, the Symposium denomination core Server certification additionally exams the structure, custom configuration and integration of the server. To flux either of those certifications, one examination should exist efficiently completed: Symposium call seat or Symposium denomination core installing and maintenance, respectively.

NNCSS - Symposium call core TAPI/Agent or call middle TAPI/Agent setting up and protection

These two certifications examine the means to reserve in force, function, and troubleshoot the Symposium denomination core TAPI/Agent. each certifications cowl hardware, application installing, administration, and maintenance of Symposium TAPI 2.three and Symposium Agent 2.three. youngsters, the Symposium denomination core TAPI/Agent certification additionally assessments the structure, integration, and customized configuration of the TAPI/Agent. To circulate both of these certifications, one exam must exist effectively accomplished: Symposium denomination core TAPI/Agent or Symposium denomination middle TAPI/Agent Inst/main, respectively.

NNCSS - Symposium specific denomination middle or Symposium express denomination core installing and renovation

These certifications check the means to enforce, function, and troubleshoot the Symposium categorical call core. both certifications cover hardware, application installation, administration, and protection of Symposium express denomination core four.2. despite the fact, the Symposium categorical call core certification besides assessments the structure and integration of the call middle. To whisk either of the certifications, one exam believe to exist successfully achieved: Symposium express denomination core or Symposium specific call core Inst and Maint respectively.

NNCSS - VoIP Multimedia communique Server (MCS) 5100 2.0

This certification exams the means to implement, function, and troubleshoot the VoIP Multimedia verbal exchange Server (MCS) 5100 2.0. This certification covers installing of the hardware and utility, configuration, protection, and administration of the Multimedia conversation Server (MCS) 5100 2.0. To whisk the certification, two tests should exist successfully accomplished: technology requisites and Protocols for IP Telephony solutions, and VoIP Multimedia communique Server (MCS) 5100 2.0. The technology specifications and Protocols for IP Telephony solutions examination is an overview of convergence applied sciences.

NNCSS - VoIP Succession a thousand/1000M Rls. three.0 DB Administrator

This certification tests the skill to maintain and troubleshoot the VoIP Succession 1000/1000M Rls. 3.0 DB Administrator. This certification covers the architecture, configuration, renovation, and management of the Meridian 1, Succession one thousand Rls. 3.0, and Succession 1000M Rls. three.0 the utilize of fundamental Alternate Route preference (BARS) and community Alternate Route alternative (NARS). To whisk the certification, two tests should exist effectively accomplished: technology necessities and Protocols for IP Telephony options, and Succession a thousand/1000M Rls. 3.0 DB Administrator.

NNCSS - VoIP Succession a thousand/1000M Rls. 3.0 installation and protection

This certification tests the capacity to set up, configure, and retain the VoIP Succession 1000/1000M Rls. 3.0. This certification covers the installation, architecture, configuration, protection, and administration of the Meridian 1, Succession 1000 Rls. 3.0, and Succession 1000M Rls. 3.0, cyber web Telephones i2xxx, and Optivity Telephony manager (OTM) 2.1. To pass the certification, three assessments need to exist effectively accomplished: know-how requisites and Protocols for IP Telephony options, and Succession one thousand/1000M Rls. 3.0 for Technicians, and Succession one thousand/1000M Rls. three.0.

guide knowledgeable

The aid professional certifications build on the expert's capabilities through demonstrating their capacity to reserve into effect, operate, and troubleshoot an superior Nortel Networks IP Telephony solution. The assuage professional certifications mirror a candidate with six to 12 months of palms-on adventure with the capacity to steer or assuage intermediate-level personnel to preserve intricate Nortel IP Telephony solutions.

NNCSE - CallPilot 2.0 Unified Messaging solutions

This certification checks the capability to implement, operate, troubleshoot and optimize the VoIP CallPilot Unified Messaging reply 2.0. This certification covers the setting up, administration, interoperability, security, upgrade approaches and believe usage for a multi website CallPilot gadget. To pass the certification, the candidate should first acquire their NNCSS - CallPilot Rls. 2.0. as a result, the CallPilot 2.0 Unified Messaging options ought to exist effectively accomplished to obtain this certification.

NNCSE - Contact middle

This certification assessments the capacity to reserve in force, operate, troubleshoot and optimize the Contact core products. This certification covers the candidate's capabilities on the Symposium call core Server (SCCS)/Symposium specific call core/Symposium web customer, Symposium TAPI service issuer (TAPI SP), Symposium Agent, and the Symposium web core Portal. To circulate the certification, the candidate must first achieve their NNCSS - Symposium denomination middle Server and the NNCSS - Symposium call seat TAPI/Agent certification. consequently, the Contact seat examination should exist correctly completed to gain this certification.

NNCSE - IP Convergence Succession 1000/1000M Rls. three.0

This certification exams the capacity to installation, configure, retain, and optimize the VoIP Succession 1000/1000M Rls. three.0. This certification covers the configuration, succession fork workplace (BO), remote workplace, operation, and Meridian 1 to Succession 1000M 3.0 migration approaches for the Succession one thousand/1000M Rls. 3.0, information superhighway Telephones i2xxx, faraway workplace 91xx, and Optivity Telephony manager (OTM) 2.1. To pass the certification, the candidate must first gather their NNCSS - VoIP Succession CSE one thousand Rls. 2.0 or the VoIP Succession 1000/1000M Rls. three.0 setting up & upkeep certification. in consequence, an additional more complicated version of the Succession a thousand/1000M Rls. 3.0 exam ought to exist successfully achieved to gather this certification.

within the IT business, certifications are a means to validate someone's scholarship inside a special area. The above Nortel IP Telephony certifications are one of the most paraphernalia that may demonstrate the capabilities of an IP Telephony back expert. These certifications couldn't change years of trade adventure, however they attain give the foundation to assuage and manage Nortel Voice over IP options.

The next tip will focus on Nortel's Design IP Telephony certification song.

Richard Parsons (CCIE#5719) is a manager of knowledgeable functions for Callisma Inc., a totally owned subsidiary of SBC. He has constructed an exceptional basis in networking ideas, advanced troubleshooting, and monitoring in areas corresponding to optical, ATM, VoIP, routed, routing, and storage infrastructures. prosperous resides in Atlanta GA, and is a graduate of Clemson university. His history contains senior and major consulting positions at international network functions, Lucent, and Callisma.


Nortel convention call: Pragmatically Bullish | killexams.com actual Questions and Pass4sure dumps

No influence found, are attempting modern key phrase!I’ll travel away it to the analysts to feed Nortel’s (NT) third-quarter financials into their models. as a substitute, I’ll present my concepts on the tone of the convention name. overall, I’d whisper it turned into a pragmatica...

Symon Communications joins Nortel select Product program in EMEA | killexams.com actual Questions and Pass4sure dumps

LONDON--(business WIRE)--June 14, 2005--Symon Communications Ltd, a number one world provider of precise-time communications options for the call centre trade, has been chosen by Nortel (NYSE:NT)(TSX:NT) to link its select Product application (SPP) in Europe, the core East and Africa (EMEA).

The programme is the properly tier of Nortel's Developer application, which gives contributors with the probability to forward and carry main-area customer solutions. Symon's preference turned into in keeping with Nortel's evaluation of Symon's trade goal as well as client enter.

"This announcement is very vital for Symon and Nortel customers alike," said Nelson Smelker, UK managing director, Symon Communications. "The indisputable fact that Symon and their real-time products are being tremendously recommended through Nortel illustrates the confidence that the resellers and their purchasers believe in their items. Nortel is one in every of their closest companions and they correspond with that their inclusion on the opt for Product application in Europe demonstrates that they are a official and committed companion, in for the long haul."

"we're at entire times trying to simplify the course they travail with their channel companions to exist able to deliver altenative and top mighty overall solutions to their conclusion consumers," observed Paul Templeton, vice president, trade solutions, EMEA, Nortel. "we are very excited to believe Symon Communications exist a section of the EMEA opt for Product application, a strategic initiative peculiarly designed to give their customers access to advised third-celebration items by the utilize of Nortel channel partners."

The select Product program permits reduced in size Nortel Resellers (CNRs) to order suitable third-birthday party products below special phrases and stipulations of sale that strategically complement the Nortel product portfolio and create gigantic cost for its consumers. select products are defined as Nortel's most highly suggested third-party products for a particular performance. items in Symon's award-profitable actual-time communications portfolio, which comprises Symon commercial enterprise Server (SES), Symon Vista and Symon TargetVision, believe entire been chosen as select products by using Nortel.

additionally, Symon's newest corpse of workers management answer, Symon group, has been given an Orderable suitable designation, permitting the reply to exist ordered direct by means of Nortel ordering methods.

Symon has been a a success registered member of Nortel's EMEA Developer program since July 2004. Nortel's Developer software has labored with imaginative corporations that complement and lengthen its product portfolio for over 20 years. The Developer program formalizes these associate relationships, providing an excellent partnering framework that promotes solutions with plenary compatibility between components.

The Nortel Developer software has different ranges of membership, ranging from the entry degree, base tier, Open Developer, the residence builders profit access to a lot of tools to facilitate their building efforts, via to Developer associate stage, where Nortel actively markets the Developer accomplice products. one of the crucial pre-requisites for Developer partner popularity is the successful completion of compatibility trying out, which increases client self assurance within the built-in answer. eventually, developers might besides graduate by invitation most efficacious to the opt for Product program level, which is the remedy tier of the Developer application. Nortel select items are strategic building blocks for Nortel imaginative architecture and back in proposing shoppers with essentially the most beneficial and efficient solution for his or her communication wants. For more recommendation on entire Nortel opt for products, tickle consult with www.nortel.com/choose. For additional assistance on the Developer application, tickle visit www.nortel.com/prd/dpp.

About Symon Communications

Symon Communications Ltd, primarily based in Beckenham, UK, produces mighty utility and hardware solutions to bring together, analyse, file and song actual-time, mission-essential productiveness recommendation for contact centres and different enterprise functions. This assistance contains enterprise metrics, workforce effectivity and operations indicators.

Symon Communications' award-profitable products consist of browser-based Symon neighborhood group of workers administration application and Symon Vista facts presentation tools, Symon TargetVision visible messaging methods, patented Symon NetLite II wallboards, Symon DeskView visual computing device messaging and alerting software and the Symon trade Server records management system.

installed in additional than 6,000 centres global, more than 4 million shoppers view Symon Communications' items every day. clients encompass Kwik healthy, American express, Eli Lilly, Deutsche Telekom and Royal Mail community.

Symon Communications Ltd. is a wholly owned subsidiary of Symon Communications Inc. based out of Plano, Texas.

About Nortel

Nortel is a recognized chief in supplying communications capabilities that enlarge the human journey, ignite and power world commerce, and at ease and present protection to the area's most primary tips. Serving both provider issuer and trade valued clientele, Nortel provides ingenious technology solutions encompassing end-to-end broadband, Voice over IP, multimedia services and functions, and instant broadband designed to aid individuals clear up the realm's surest challenges. Nortel does trade in more than a hundred and fifty nations. For greater assistance, search recommendation from Nortel on the net at www.nortel.com. For the newest Nortel news, consult with www.nortel.com/news.

definite tips included in this press liberate is ahead-looking and is domain to essential risks and uncertainties. The outcomes or events predicted in these statements may disagree materially from genuine outcomes or movements. components which might cause outcomes or movements to disagree from current expectations encompass, among other things: the result of regulatory and criminal investigations and civil litigation movements related to Nortel's restatements and the believe an sequel on any resulting criminal judgments, settlements, penalties and prices may believe on Nortel's effects of operations, monetary condition and liquidity, and any connected competencies dilution of Nortel's accustomed shares; the findings of Nortel's impartial evaluation and implementation of advised remedial measures; the outcome of the independent evaluation with recognize to revenues for specific identified transactions, which evaluation will believe a specific emphasis on the underlying habits that led to the prefatory focus of those revenues; the restatement or revisions of Nortel's previously announced or filed pecuniary outcomes and resulting negative publicity; the being of fabric weaknesses in Nortel's internal manage over monetary reporting and the conclusion of Nortel's administration and independent auditor that Nortel's inner manage over pecuniary reporting is ineffective, which might proceed to impact Nortel's skill to record its effects of operations and pecuniary circumstance precisely and in a timely method; the impact of Nortel's and NNL's failure to well timed file their economic statements and related fitful studies, together with Nortel's want of capacity to access its shelf registration statement filed with the USA Securities and exchange fee (SEC); ongoing SEC studies, which may result in alterations to Nortel's and NNL's public filings; the believe an impact on of management alterations, together with the termination for explanation for Nortel's former CEO, CFO and Controller in April 2004; the sufficiency of Nortel's restructuring actions, together with the travail goal introduced on August 19, 2004 as up to date on September 30, 2004 and December 14, 2004, together with the competencies for greater genuine prices to exist incurred in reference to restructuring moves compared to the estimated charges of such movements; cautious or reduced spending with the aid of Nortel's valued clientele; increased consolidation among Nortel's shoppers and the want of valued clientele in unavoidable markets; fluctuations in Nortel's operating consequences and commonplace business, pecuniary and market situations and enlarge charges; fluctuations in Nortel's money circulate, stage of wonderful debt and current debt rankings; Nortel's monitoring of the capital markets for alternatives to enhance its capital structure and economic flexibility; Nortel's skill to recruit and continue certified employees; the utilize of cash collateral to assist Nortel's common course enterprise actions; the dependence on Nortel's subsidiaries for funding; the handle of Nortel's defined improvement plans and deferred tax property on consequences of operations and Nortel's money circulation; the adversarial decision of category actions, litigation in the ordinary direction of enterprise, intellectual property disputes and similar matters; Nortel's dependence on modern product building and its capacity to forecast market require for specific products; Nortel's means to combine the operations and technologies of got groups in an exceptional method; the influence of swift technological and market trade; the handle of rate and product competitors; obstacles to overseas enlarge and global pecuniary conditions, above entire in emerging markets and together with activity rate and quaint money alternate price fluctuations; the believe an sequel on of explanation and consolidation within the telecommunications business; alterations in law of the information superhighway; the believe an sequel on of the credit score risks of Nortel's customers and the believe an sequel on of consumer financing and commitments; inventory market volatility often and on account of acceleration of the agreement date of Nortel's forward buy contracts; poverty-stricken developments associated with Nortel's supply contracts and condense manufacturing agreements, together with because of the usage of a sole company for a key component of Definite optical networks options; the believe an impact on of Nortel's deliver and outsourcing contracts that comprise start and setting up provisions, which, if not met, might influence in the charge of sizeable penalties or liquidated damages; and the long elope success of Nortel's strategic alliances. For more information with appreciate to Definite of these and different components, view the most fresh Annual report on benign 10-okay and Quarterly file on figure 10-Q filed by course of Nortel with the SEC. unless otherwise required through applicable securities legal guidelines, Nortel disclaims any goal or responsibility to update or revise any forward-searching statements, even if as a result of modern information, future pursuits or in any other case.

Nortel, the Nortel emblem and the Globemark are emblems of Nortel Networks. Symon, Symon trade Server, Symon NetLite II, Symon group, Symon TargetVision and Symon Vista are trademarks of Symon Communications, Inc.

Use of the terms "associate" and "partnership" doesn't imply a legal partnership between Nortel and some other birthday celebration.


920-130 Symposium Express call Center

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920-130 exam Dumps Source : Symposium Express call Center

Test Code : 920-130
Test denomination : Symposium Express call Center
Vendor denomination : Nortel
: 57 actual Questions

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ZTO Express' (ZTO) CEO Meisong Lai on Q3 2018 Results - Earnings call Transcript | killexams.com actual questions and Pass4sure dumps

No result found, try modern keyword!ZTO Express (NYSE:ZTO) Q3 2018 Earnings Conference call November 14 ... their service attribute seat has been focusing on five effects throughout the year, including process implementation, resource ...

Express, Inc. Announces Earnings Release Date, Conference call and Webcast for Fourth Quarter and Fiscal Year 2017 Results | killexams.com actual questions and Pass4sure dumps

COLUMBUS, Ohio--(BUSINESS WIRE)--

Express, Inc. (EXPR), a specialty retail apparel company, today announced that it will conduct a conference call to dispute fourth quarter and fiscal year 2017 results on Wednesday, March 14, 2018, at 9:00 a.m. Eastern Time (ET). Earlier that morning, the Company will issue a press release detailing those results. The conference call will exist hosted by David Kornberg, president and chief executive officer, Matthew Moellering, executive vice president and chief operating officer, and Perry Pericleous, senior vice president and chief pecuniary officer.

Investors and analysts interested in participating in the call are invited to dial (877) 705-6003 approximately ten minutes prior to the start of the call. The conference call will besides exist webcast live at: http://www.express.com/investor and remain available for 90 days. A telephone replay of this call will exist available at 12:00 p.m. ET on March 14, 2018, until 11:59 p.m. ET on March 21, 2018, and can exist accessed by dialing (844) 512-2921 and entering the replay pin number 13676416.

In addition, an investor presentation of fourth quarter and fiscal year 2017 results will exist available at: http://www.express.com/investor at approximately 7:00 a.m. ET on Wednesday, March 14, 2018.

About Express, Inc.:

Express is a specialty retailer of women's and men's apparel and accessories, targeting the 20 to 30-year-old customer. Express has more than 35 years of flavor offering a distinct combination of fashion and attribute for multiple lifestyle occasions at an attractive value addressing fashion needs across work, casual, jeanswear, and going-out occasions. The Company currently operates more than 600 retail and factory outlet stores, located primarily in high-traffic shopping malls, lifestyle centers, and street locations across the United States and Puerto Rico. Express merchandise is besides available at franchise locations and online in Latin America. Express besides markets and sells its products through its e-commerce website, www.express.com, as well as on its mobile app.

View source version on businesswire.com: http://www.businesswire.com/news/home/20180222005285/en/


Regeneron Pharmaceuticals Inc (REGN) Q3 2018 Earnings Conference call Transcript | killexams.com actual questions and Pass4sure dumps

Logo of jester cap with thought bubble.© The Motley Fool Logo of jester cap with thought bubble.

Regeneron Pharmaceuticals Inc  (NASDAQ: REGN)

Q3 2018 Earnings Conference Call

Nov. 06, 2018, 8:30 a.m. ET

Regeneron Pharmaceuticals Inc

Contents:
  • Prepared Remarks
  • Questions and Answers
  • Call Participants
  • Prepared Remarks:

    Operator

    Welcome to the Regeneron Pharmaceuticals Q3 2018 Earnings Conference Call. My denomination is John, and I'll exist your operator for today's call. (Operator Instructions)

    And I will now gyrate the call over to Manisha Narasimhan, Head of Investor Relations.

    Manisha Narasimhan -- Head of Investor Relations

    Thank you, John. capable morning, and welcome to Regeneron Pharmaceuticals Third Quarter 2018 Conference Call. An archive of this webcast will exist available on their website under Events for 30 days.

    Joining me on the call today are Dr. Leonard Schleifer, Founder, President and Chief Executive Officer; Dr. George Yancopoulos, Founding Scientist, President and Chief Scientific Officer; Marion McCourt, Senior Vice President and Head of Commercial; and Bob Landry, Senior Vice President and Chief pecuniary Officer. After their prepared remarks, they will open the call for mp;A.

    I would besides relish to remind you that remarks made on this call today comprise forward-looking statements about Regeneron. Such statements may include, but are not limited to, those related to Regeneron and its products and business, pecuniary forecast and guidance, progress programs and related anticipated milestones, collaborations, finances, regulatory matters, intellectual property, pending litigation and competition. Each forward-looking statement is subject to risks and uncertainties that could cause actual results and events to disagree materially from those projected in that statement. A more complete description of these and other material risks can exist found in Regeneron's filings with the United States Securities and Exchange Commission, or SEC, including its figure 10-Q for the quarter ended September 30, 2018, which was filed with the SEC later today. Regeneron does not undertake any responsibility to update publicly any forward-looking statements, whether as a result of modern information, future events or otherwise.

    In addition, tickle note that GAAP and non-GAAP measures will exist discussed in today's call. Information regarding their utilize of non-GAAP pecuniary measures and a reconciliation of those measures to GAAP is available in their pecuniary results press release, which can exist accessed on their website.

    Once their call concludes, Bob Landry and the IR team will exist available to reply further questions.

    With that, let me gyrate the call over to their President and Chief Executive Officer, Dr. Len Schleifer.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Thank you. Manisha does such a fabulous job, Investor Relations. They should at least rep her denomination right. It's Manisha Narasimhan. capable morning to everyone who has joined the call.

    In the third quarter, Regeneron delivered record pecuniary results and primary pipeline progress. EYLEA sales continued to grow. For the first time, US EYLEA net quarterly sales surpassed $1 billion. besides for the first time, third quarter worldwide Dupixent sales exceeded $0.25 billion. And Dupixent was recently approved for asthma, its second major indication. Additionally, they launched Libtayo, their first approved immuno-oncology therapy.

    For EYLEA, they significantly strengthened the franchise to a recently expanded label for less frequent dosing and the potential for a modern indication in diabetic retinopathy, and they await to forward a lofty dose formulation of aflibercept into the clinic in the first half of next year.

    Libtayo, their first commercial entry into the exciting and hastily evolving district of immuno-oncology, is the foundation upon which they intend to build with multiple additional agents and approaches in many different cancer settings.

    We believe described Dupixent as a pipeline in the product and it is vital up to that potential. Compared to other approved biologics for asthma, Dupixent has a differentiated profile and label. The recent asthma approval, together with the ongoing robust launch in atopic dermatitis, positive aspect 3 results in chronic rhinosinusitis with nasal polyps and positive aspect 2 results in eosinophilic esophagitis, validate the scientific hypothesis that the IL-4/IL-13 pathway is answerable for a spectrum of allergic or type 2 diseases. You'll hear more from Marion about the launch of Dupixent in asthma in atopic dermatitis, and George will update you on their clinical programs.

    We've continued to create constant progress with their other commercialized products. For Praluent, their LDL-cholesterol lowering PCSK9 antibody, they anticipate that the US treatment guidelines for lipid-lowering will exist updated shortly. They hope the updated guidelines will facilitate greater access and back increased utilize of the PCSK9 class. Although it gets drowned out in the debate about drug prices, the fact remains that cardiovascular disease is the number one cause of death in United States and lofty LDL-cholesterol is a major cause of cardiovascular disease.

    Our earlier pipeline continues to progress. At the rise of the year, they set a goal of advancing four to six modern molecules into clinical development. I'm gay to report that to date they believe already advanced four modern molecules into clinical development. These comprise a bispecific antibody for ovarian cancer, a modern antibody for pain, a leptin receptor agonist, and an antibody to CTLA4. They besides await to forward into the clinic by year nigh at BCMA, CD3 bispecific antibody for multiple myeloma. They now believe seven approved drugs and their clinical pipeline has 20 product candidates spanning a rage of -- a orbit of therapeutic areas. entire of these molecules were discovered by their scientists.

    With that, I will now gyrate the call over to George.

    George D. Yancopoulos -- President and Chief Scientific Officer

    Thanks, Len, and capable morning, everyone.

    I'd relish to start with EYLEA. In August, their supplemental biological application, or sBLA, was approved for EYLEA dose every 12 weeks after one year of efficacious therapy in dank age-related macular degeneration, or dank AMD. EYLEA is now the only anti-VEGF drug for the treatment of dank AMD that offers the flexibility to optimally handle patients, regardless of whether they require fixed interval dosing of four, eight, or 12 weeks. In September, the FDA accepted their sBLA for EYLEA in diabetic retinopathy, with an action date in May 2019. This sBLA was based on the data from the aspect 3 PANORAMA study, which investigated the utilize of EYLEA in patients with moderately ascetic to ascetic non-proliferative diabetic retinopathy without diabetic macular edema. Positive six-month top line results from PANORAMA were announced in March 2018. Just a pair of weeks ago, they announced positive data from the one-year time point from the selfsame study. And the primary endpoint at one year, after initial monthly dosing age followed by every eight or every 16-week treatment, 80% and 65% of patients respectively experienced a two-step or greater improvement from baseline on the diabetic retinopathy severity scale compared to only 15% of patients receiving sham injections. The results were highly statistically significant with a p-value less than 0.0001.

    Regarding the two key secondary endpoints, which achieved statistical significance based on the pre-specified hierarchical analysis compared to sham injection, treatment with EYLEA reduced vision-threatening complications by 82% to 85% and the progress of center-involved diabetic macular edema by 68% to 74%. Diabetic retinopathy is the leading cause of blindness in working-age adults in the United States. What is perhaps underappreciated is the rate at which non-symptomatic patients can develop earnest complications that intimidate their vision. Strikingly, within the first year of PANORAMA, more than one-third of previously asymptomatic diabetic retinopathy patients who were treated with EYLEA went on to develop vision-threatening complications, or diabetic macular edema. EYLEA markedly reduced these complications and reversed the anatomic severity of the disease. These results underscore the potential value of earlier intervention in diabetic retinopathy. In addition to data from their PANORAMA study, the government-funded Diabetic Retinopathy Clinical Research Network is conducting its own aspect 3 study of EYLEA in diabetic retinopathy. This study known as Protocol W is ongoing.

    Turning to the competitive landscape, in their view, there is an nigh product in the near term that can believe a substantially different safety and efficacy profile compared to EYLEA. EYLEA is approved in a number of retinal diseases and has demonstrated safety and efficacy with over 20 million doses administered worldwide. It doesn't loom that any potential near-term entrants can provide substantially different dosing flexibility, duration or visual gains that are already achievable with EYLEA. Nevertheless, they believe that higher dose formulations of aflibercept might provide additional or longer-lasting benefit, and thus, they are advancing this program into clinical progress in 2019.

    I'd now relish to gyrate to Dupixent, their antibody that blocks the interleukin-4/interleukin-13 pathway that they are investigating in multiple allergic diseases. Just a pair of weeks ago, Dupixent was approved by the FDA for its second major indication, asthma in adults and in adolescents. Dupixent is approved for two primary types of patients with uncontrolled asthma, those with temper to ascetic disease within eosinophilic phenotype and those who require oral corticosteroids to manage their disease. With Dupixent, the newest biologic approved for the treatment of asthma, they believe demonstrated an unprecedented profile. As renowned in their label, in their pivotal studies of patients with temper to ascetic eosinophilic asthma, they reduced ascetic exacerbations by up to 67% compared to placebo, and increased FEV1, a measure of lung office critical in asthma by 29% to 33% compared to 14% to 16% for placebo.

    In addition, Dupixent is the only biological approved oral corticosteroid-dependent asthma regardless of eosinophilic phenotype and the only asthma biological that offers patients self-administration. The US launch in asthma is under way, as you will hear from Marion. Their regulatory application for asthma is currently under review by European regulators. They await a decision in the second quarter of 2019. In terms of ongoing clinical progress of Dupixent in asthma, they are currently enrolling patients between the ages of six and 11 years, and are planning a divide aspect 3 study in patients aged six months to five years.

    In October, they announced that, in two aspect 3 studies of Dupixent in chronic rhinosinusitis with nasal polyps, Dupixent significantly reduced nasal polyp size, nasal congestion severity and need for systemic corticosteroids and/or surgery. Patients with inadequately controlled disease struggle with pain, nasal discharge, the inability to scent and hardship breathing. The current yardstick of care, which includes the utilize of oral and intranasal corticosteroids, often along with surgery is often inadequate. These are the first pivotal crucible results in chronic rhinosinusitis with nasal polyps showing that interleukin-4 and interleukin-13 are key drivers of this disease. Of note, more than three quarters of patients in these trials besides suffer from other type 2 inflammatory conditions, including asthma, allergic rhinitis and NSAID-exacerbated respiratory disease. In a pre-specified group of patients with comorbid asthma, Dupixent significantly improved lung office asthma control, providing the first evidence that Dupixent can handle inflammation from the upper to the lower airway in the selfsame patient. circumstantial results for the nasal polyp studies will exist presented at a future medical conference. They intend to create a regulatory submission to the FDA in this indication in the first quarter of 2019.

    Dupixent has now demonstrated late-stage safety and efficacy in three allergic or atopic or type 2 inflammatory diseases, atopic dermatitis, asthma, and now chronic rhinosinusitis with nasal polyps. As they believe observed in their studies, patient with one such condition often suffer from allergic diseases as well -- other allergic diseases. They are committed to extending Dupixent's approval into younger age groups and geographies and broadening it to additional type II allergic indications. In atopic dermatitis, they recently reported positive data from aspect 3 study of Dupixent in adolescents with moderate-to-severe atopic dermatitis. These results were the basis of a regulatory submission in the US for patients between the ages of 12 and 17 years. This morning, they announced that the FDA has accepted for prior review the sBLA for Dupixent in adolescent patients 12 to 17 years of age with moderate-to-severe atopic dermatitis, whose disease was inadequately controlled with topical therapies or for whom topical treatment was medically inadvisable. Currently, there are no FDA-approved systemic biologic medicines to handle adolescents with moderate-to-severe atopic dermatitis. The target date for the FDA decision is March 11, 2019. We're besides currently conducting studies in younger patients between the ages of six months and five years, as well as in patients between the ages of six and 11 years. In terms of other diseases, they initiated their aspect 2/3 study of dupilumab in adults and adolescents with eosinophilic esophagitis. They besides recently started their aspect 2 study of dupilumab in peanut allergy. This program is being conducted in collaboration with Aimmune Therapeutics. A aspect 2 study of dupilumab for grass allergy is currently under course and a aspect 2/3 study in COPD is being planned.

    We view their interleukin-33 program as a complement to Dupixent. The Regeneron Genetics seat in collaboration with Geisinger Health System and the UK Biobank has confirmed an extended observations linking the interleukin-33 pathway to both COPD and asthma. They are studying their interleukin-33 antibody both as monotherapy as well as in combination with Dupixent in asthma, where they believe three trials in progress; and in COPD, where they believe one. They planned, by year end, to initiate two aspect 2 studies in atopic dermatitis, one will exist anti-IL-33 monotherapy and the other will combine anti-IL-33 with Dupixent.

    I would now relish to switch to the very exciting fields of immuno-oncology, which continues to exist an district of focus for us and where they believe recently made primary strides. At the nigh of September, Libtayo, the brand denomination is cemiplimab-rwlc, became not only the first PD-1 antibody approved by the FDA for the treatment of advanced cutaneous squamous cell carcinoma, where CSCC, with the first treatment of any kind, ever approved for this cancer. The response rate for this very lofty unmet need cancer setting were among the highest ever reported for PD-1 treatment in solid tumor. Outside the United States, a regulatory application for Libtayo is being reviewed by the European Medicines Agency, with a decision expected in the first half of 2019. There are currently no EMA approved treatments for advanced cutaneous squamous (ph) carcinoma.

    As they believe stated before, they consider non-small cell lung cancer to exist an primary potential modern indication for Libtayo. Their aspect 3 program in non-small cell lung cancer is enrolling as planned. Based on their review of emerging data in this evolving field, and as they had indicated on their terminal quarterly call, they believe doubled the size of their crucible comparing Libtayo monotherapy to chemotherapy in PDL-1 lofty patients from 300 patients to approximately 700 patients. They are besides conducting aspect 3 studies of Libtayo in second-line non-small cell lung cancer and in combination with chemotherapy and with an anti-CTLA4 antibody in first-line. While these studies are being conducted with the commercially available CTLA4 antibody, I am pleased to report that their own CTLA4 antibody is now in clinical development.

    Turning now to their bispecific antibody platform. The leading program here is their fully owned CD20xCD3 antibody. Next month, at the annual meeting of the American Society of Hematology, or ASH, they will exist presenting additional data in B-cell malignancies. Their second bispecific antibody to enter the clinic targets MUC16 and CD3 for ovarian cancer. By year-end, they await their by BCMAxCD3 bispecific antibody to enter clinical progress for the treatment of multiple myeloma. They believe besides announced that they will exist progressing an entirely modern class of bispecifics into the clinic starting in the first half of 2019. Continuing on the theme with immuno-oncology, in the third quarter, they entered into a collaboration with bluebird bio to discover, develop and commercialize modern CAR T and other cell therapies for cancer. This collaboration represents a mighty illustration of two companies with synergistic technologies working together to try to create a significant advancement in the field.

    Moving on, their late-stage pipeline has made progress and I would relish to focus on a few programs. In the third quarter, they announced positive top line efficacy data for fasinumab, a Nerve Growth Factor, or NGF antibody in patients with chronic stitch from osteoarthritis of the knee or hip. The study met both co-primary endpoints and entire key secondary endpoints at week 16, showing that they can achieve efficacy with low doses that mitigate treatment associated arthropathy at least during the study period. They believe three aspect 3 studies with fasinumab ongoing in osteoarthritis, including their long-term safety study. As most of you know, stitch represents an district of lofty unmet need. To that end, they believe recently advanced another molecule for stitch into clinical development, a fully human antibody to the GFRalpha-3 neurotrophic factor receptor.

    Our clinical programs in cardiovascular metabolism are poignant ahead. They are enrolling aspect 3 studies of Praluent in adults with homozygous familial hypercholesterolemia in addition to pediatric studies in heterozygous and homozygous familial hypercholesterolemia. They recently received regulatory approval for Praluent for the treatment of patients with heterozygous familial hypercholesterolemia undergoing apheresis. And finally, the FDA has accepted for review an sBLA for Praluent as a potential treatment to reduce major adverse cardiovascular events with a target action date of April 28, 2019. Evinacumab, their ANGPTL3 antibody is in the aspect 3 clinical progress study in homozygous familial hypercholesterolemia, where it has received orphan and breakthrough designations. They were besides enrolling patients in the aspect 2 study of evinacumab in heterozygous familial hypercholesterolemia and refractory hypercholesterolemia, and in another aspect 2 study in ascetic hypertriglyceridemia.

    In terms of their other clinical programs, in December, at the annual ASH meeting, we'll besides exist presenting additional data from their wholly owned C5 antibody program. They await to initiate a aspect 2 study of the subcutaneously administered molecule in patients with paroxysmal nocturnal hemoglobinuria, or PNH, in the first half of 2019. Another exciting molecule in their pipeline is their Activin A antibody, where they currently believe a potentially pivotal aspect 2 study ongoing in a rare disease called fibrodysplasia ossificans progressiva. Finally, I would just relish to highlight, within the next three months, their Regeneron Genetics seat expects to hit the 500,000 heed of humans sequenced, a milestone few, if any, centers believe ever achieved.

    With that, I would now relish to gyrate the call over to Marion.

    Marion McCourt -- Senior Vice President and Head of the Commercial organization

    Thank you, George, and capable morning, everyone.

    I'd relish to start with EYLEA, where global net sales in the third quarter were $1.68 billion, an enlarge of 11% year-over-year. US net sales for EYLEA were $1.02 billion, a 7% year-over-year increase. This enlarge was driven by overall market growth in both dank AMD and DME, physician preference and the aging population, as well as the enlarge in the prevalence of diabetes. Based on net sales, EYLEA currently holds about 70% of the overall branded US anti-VEGF market.

    In an effort to educate consumers and raise brand awareness and interest, they recently launched a pilot EYLEA DTC push for approved indications in select markets. Beyond the approved indications of dank AMD, DME, retinal vein occlusion and diabetic retinopathy with DME, they view potential opportunities for EYLEA in diabetic retinopathy. As you just heard from George, they recently reported positive data in this indication and await a regulatory decision in the US in May of next year. Following this potential approval, they goal to initiate a focused push to drive adoption in this big untapped indication. Additionally, in August, they announced that the FDA approved an sBLA for EYLEA for a modified every 12-week dosing schedule for dank AMD after one year of efficacious treatment. This makes EYLEA the only approved anti-VEGF drugs for dank AMD with four, eight and 12-week dosing, specifically referenced in its label.

    I'd relish to expend a jiffy discussing their pre-filled syringe for EYLEA. As previously announced, they received a complete response letter from the FDA. They remain confident that they will exist able to fullfil the agency's request, which included the completion of a usability study evaluating a sole injection in approximately 30 patients. They goal to create a regulatory submission in the first half of 2019. Their launch timelines for the pre-filled syringe believe not changed, and they continue to exist on track for an expected 2019 launch.

    Turning now to Dupixent. Global net sales in the third quarter of 2018, as reported by their collaborator Sanofi, were $263 million, including $220 million in US. Let me start with Dupixent in atopic dermatitis. Underlying US require for Dupixent remains strong, with total prescriptions, or TRx, up approximately 17% quarter-over-quarter sequentially. Prescriber depth and breadth continues to ameliorate with now over 12,300 healthcare providers having prescribed Dupixent to over 60,000 patients. Despite the energy of this launch, the vast majority of patients with moderate-to-severe atopic dermatitis believe not been treated with Dupixent. Educating patients about Dupixent as a potential modern treatment is an primary district of focus. To this end, they recently launched a national branded television push and are encouraged by the early results. Outside the US, the ongoing launch in Dupixent in atopic dermatitis is progressing well. As George announced, the sBLA for Dupixent in adolescents with atopic dermatitis has been filed and granted priority review by the FDA, with an action date in March 2019. If approved, this will allow the benefits to Dupixent to exist extended to patients as adolescent as 12 years of age. They evaluate that the number of adolescent patients is about half that of the adult atopic dermatitis population. In addition, they believe besides submitted an application for a 200-milligram auto-injector for Dupixent.

    Turning now to asthma, which is the most recently approved indication for Dupixent. As you heard from George, they believe Dupixent is a highly differentiated biologic for the treatment of asthma. The launch is under way, and feedback from physicians has been positive. We've only been in the market for a pair of weeks now, so it is too early to provide any circumstantial launch metrics. They evaluate there are approximately 775,000 to 900,000 adult and adolescent patients in the US with moderate-to-severe asthma that believe uncontrolled persistent symptoms that, despite yardstick of confidence therapy, may exist suitable for treatment with a biologic therapy. Currently, only about 11% of these patients are treated with a biologic. One of the key considerations for physicians treating asthma patients is to circumscribe or avoid the utilize of oral steroids to control the disease. They evaluate that the oral corticosteroid-dependent population represents approximately 25% to 30% of the approximate 775,000 to 900,000 patients with uncontrolled persistent asthma eligible for a biologic. Dupixent is a non-steroid treatment option for these patients. With that in mind, they are optimistic about the asthma launch, with the goal of making Dupixent a preferred first-line biologic for indicated patients with moderate-to-severe asthma. Early efforts to engage both allergists and pulmonologists are well under course and the reception has been positive. Many allergists are already intimate with Dupixent in atopic dermatitis, and these doctors are besides treating patients with asthma. We're actively working on educating and creating awareness of Dupixent's differentiated profile with pulmonologists. They recognize forward to providing further updates on the launch in the months ahead.

    I'd now relish to gyrate to Libtayo, their PD-1 antibody. On September 28th, the FDA approved Libtayo for the treatment of patients with metastatic cutaneous squamous cell carcinoma, or locally advanced CSCC who are not candidates for curative surgery or curative radiation. They continue to await a decision by the European Medicines Agency in the first half of 2019. The launch of Libtayo is a major milestone and a first step in their goal of establishing Regeneron as a major player in the immuno-oncology space. Upon FDA approval, the oncology sales accommodate quickly mobilized to create Libtayo the yardstick of confidence for CSCC by engaging medical oncologists and MO (ph) surgeons targeting centers specializing in skin cancers. So far, feedback from medical community has been positive. On October 24th, Libtayo was included in the updated National Comprehensive Cancer Network, NCCN guidelines for CSCC. Libtayo received a 2A evidence rating, the only systemic therapy with an NCCN rating in CSCC. From a payer standpoint, we've been successful in establishing broad access and reimbursement coverage, so patients in need can rep access to the treatment quickly. Recall that CSCC is the most common figure of skin cancer and is answerable for an estimated 4,000 to 8,000 deaths each year in the US. It currently accounts for approximately 20% of entire skin cancers in the US, with the number of newly diagnosed cases expected rise annually. They recognize forward to providing further updates on the launch at a later time.

    Switching to Praluent. Global net sales in the third quarter recorded by Sanofi were $80 million, representing a 62% enlarge compared with the third quarter of 2017. They believe submitted data from the cardiovascular outcome study to regulatory agencies in the US and the EU and anticipate decisions in the second half of 2019. They are besides expecting that the lipid-lowering treatment guidelines in the US will exist updated shortly. These updated guidelines may facilitate greater access and back increased utilize of the PCSK9 inhibitor class. We're continuing payer assignation and remain the exclusive PCSK9 inhibitor on the Express Scripts national commercial formulary. Based on net sales, their market share in the US has grown significantly since the addition to the ESI formulary up to 40% in the third quarter, with the number of prescriptions continuing to enlarge steadily.

    Moving to Kevzara, global net sales, as recorded by Sanofi, were $25 million in the third quarter as require improved. Within the IL-6 subcutaneous class, Kevzara now has 42% of dispensed NBRx share and 20% share of TRx.

    I'll now gyrate the call over to Bob.

    Robert E. Landry -- Senior Vice President, Finance and Chief pecuniary Officer

    Thanks, Marion, and capable morning, everyone.

    I'm pleased to report both solid top line results and sturdy operational performance for the third quarter of 2018. They are encouraged by EYLEA and Dupixent sales growth, progress across their portfolio and improvements in their operating leverage as reflected in the reduction of their full-year 2018 expense and tax guidance line items.

    For the third quarter of 2018, they earned $5.87 per diluted share on non-GAAP net income of $675 million. These results delineate a 47% and 44% year-over-year enlarge in their non-GAAP diluted EPS and net income, respectively. Total revenue grew 11% year-over-year to $1.66 billion, driven by performance of US EYLEA, revenue increases for both the Sanofi and Bayer collaborations and growth within other revenue.

    EYLEA net product sales in the United States grew 7% to $1.02 billion compared to $953 million in the third quarter of 2017. US EYLEA distributor inventory decreased in the quarter as compared to the second quarter of 2018 yet remained within their routine one to two-week targeted range. As disclosed in their terminal earnings call, commencing in the second week of June, they increased the existing EYLEA discount that they present to physician practices regardless of volume. As a result, there was a slight degradation in EYLEA's aboriginal to net percentage in the third quarter of 2018 compared to both the third quarter of 2017 and the first half of 2018. efficacious October 1, 2018, they started shipping and recording US net sales of Libtayo. As a reminder, for Libtayo in the US, they are the commercial lead and will record product sales. Sanofi has exercised its option to co-promote Libtayo in the US. Ex-US EYLEA net product sales, recorded by their collaborator Bayer, were $655 million for the three months ended September 30, 2018, representing a 20% operational and 16% reported enlarge on a year-over-year basis.

    Total Bayer collaboration revenue for the three months ended September 30, 2018 grew 12% year-over-year to $264 million, of which $243 million was derived from the share of net profits from EYLEA sales outside the US. The $243 million, which represents year-over-year growth of 18%, compares favorably to the $205 million realized for the three months ended September 30, 2017.

    Total Sanofi collaboration revenue was $256 million for the third quarter of 2018 compared to $245 million for the third quarter of 2017. The year-over-year revenue enlarge was driven by three factors. First, they realized a $59 million diminish in their share of losses in connection with the commercialization of Dupixent, Praluent and Kevzara; second, higher Sanofi R&D reimbursement revenue associated with their increased investment in immuno-oncology; and third, higher Sanofi commercialization reimbursement revenue associated with increased investment in commercialized products. Offsetting these three factors is the 2017 expiration of the Sanofi Antibody Discovery and Preclinical progress Agreement, under which they recorded $38 million of revenue in the third quarter of 2017 compared to no revenue this quarter.

    In the third quarter of 2018, they recognized a loss of $39 million in connection with the commercialization of products from the antibody license and collaboration agreement with Sanofi, which compares favorably to a loss of $98 million in the third quarter of 2017 and a loss of $69 million in the second quarter of 2018. The lower share of loss versus the third quarter of 2017 was primarily attributed to higher global net sales of Dupixent and Praluent, and continued cost containment for Praluent, partly offset by an enlarge in Dupixent commercialization expenses.

    Despite incurring necessary launch expenses for modern indications in modern markets, from a pecuniary standpoint, the alliance had its best performing quarter. While they experienced improved operating leverage in the third quarter of 2018, they await the alliance's pecuniary results to remain variable for the next few quarters as they continue to incur launch expenses for modern indications and modern markets. Compared to the third quarter of 2018, they are expecting a higher alliance loss in the fourth quarter of 2018 in connection with the commercialization of these antibodies.

    Before turning to expenses, I want (ph) to briefly remark on their third quarter 2018 other revenue. In the third quarter of 2018, other revenue was $117 million versus $62 million in the third quarter of 2017. This enlarge was primarily driven by the recognition of a higher amount of deferred revenue from Teva and Mitsubishi Tanabe, including amounts related to the recognition of a portion of the $60 million and $20 million progress milestones achieved from Teva and Mitsubishi Tanabe, respectively, in the third quarter of 2018. Other revenues besides increased from the recognition of revenue related to their agreement with Biomedical Advanced Research progress Authority, or BARDA, to develop, test and manufacture an antibody therapy for the treatment of Ebola virus infection. As a reminder, you can find a summary of the components of other revenue in the MD&A section of the 10-Q.

    Non-GAAP R&D expenses were $497 million for the third quarter of 2018 as compared to $460 million for the third quarter of 2017. The enlarge in non-GAAP R&D expense was the result of an enlarge in Libtayo clinical costs and higher R&D headcount and facility-related costs, partly offset by a diminish in Dupixent progress costs. Their non-GAAP unreimbursed R&D expense, which is calculated as the total non-GAAP R&D expense less R&D reimbursements from their collaborators, was $311 million for the three months ended September 30, 2018 compared to $227 million for the three months ended September 30, 2017. As highlighted earlier, $38 million of this enlarge is attributable to the expiration of the Sanofi Antibody Discovery and Preclinical Agreement at the nigh of 2017. The remaining increases were driven by their share of higher immuno-oncology clinical costs and R&D activities associated with the growing number of wholly owned programs. Their press release includes the information required to compute unreimbursed non-GAAP R&D expense. They are lowering and tightening their full-year 2018 guidance for non-GAAP unreimbursed R&D expense to exist in the orbit of $1.19 billion to $1.225 billion from their previous guidance of $1.21 billion to $1.26 billion.

    Non-GAAP SG&A expense was $326 million for the third quarter of 2018 as compared to $259 million for the three months ended September 30, 2017. The higher SG&A expenses in the third quarter of 2018 were primarily due to an enlarge in contributions to independent not-for-profit patient assistance organizations and higher launch expenses for Libtayo and Dupixent in adult and adolescent asthma. They are lowering and tightening their full-year 2018 non-GAAP SG&A expense to exist $1.33 billion to $1.37 billion from $1.34 billion to $1.39 billion. Based on this revised guidance, they await a higher SG&A expend even in the fourth quarter of 2018. This higher expend is driven by EYLEA expenses, including DTC, and Dupixent expenses, including DTC and patient back programs.

    Sanofi reimbursement of Regeneron commercialization-related expenses, a line item found within Sanofi collaboration revenue, was $107 million for the third quarter of 2018. They are lowering and tightening their full-year 2018 guidance for reimbursement of Regeneron commercialization-related expenses to $430 million to $455 million from $455 million to $485 million.

    For the three months ended September 30, 2018 as compared to the selfsame age in 2017, non-GAAP cost of goods sold declined principally due to better cost absorption at their Limerick, Ireland commercial manufacturing facility. Cost of collaboration and condense manufacturing increased due to higher sales volumes of both EYLEA outside the US and Sanofi collaboration antibodies, as well as the recognition of manufacturing costs associated with their agreement with BARDA. These increases were partially offset by lower validation costs at their Limerick facility.

    Turning now to taxes. Their efficacious tax rate in the third quarter 2018 was 6.5% compared to 31.3% for the third quarter of 2017, driven primarily by the enactment of the Tax Cuts and Jobs Act, as well as one-time tax benefits associated with tax planning in connection with this act. Their tax rate continues to benefit from the federal tax credit for research activities, stock-based compensation and income earned in quaint jurisdictions with tax rates lower than the US. The third quarter 2018 besides included a GAAP income tax benefit of $11.9 million that was an adjustment to the provisional amount recorded as of December 31, 2017 for the US Tax Reform Act, which was related to the remeasurement of the Company's US net deferred tax assets. As they await additional regulatory guidance and continue to assess the plenary impact of the modern tax law, including some one-time items, they now await their full-year 2018 efficacious tax rate to exist in the orbit of 11% to 13% from their previous guidance of 13% to 16%. While their efficacious tax rate guidance has been lowered for 2018, they await that, over the next few years, their efficacious tax rate will exist in the mid-to-high teens.

    Turning next to cash flux and the equipoise sheet. Regeneron ended the third quarter of 2018 with cash and marketable securities of $4.1 billion and generated in excess of $1.1 billion of free cash flux for the nine months ended September 30, 2018. They compute free cash flux as net cash provided by operating activities less capital expenditures. Their capital expenditures for the three months ended September 30, 2018 were $106 million and totaled $298 million for the nine months ended September 30, 2018. They are lowering and tightening their full-year 2018 capital expenditure guidance to $360 million to $390 million from their prior orbit of $410 million to $450 million.

    On the BD (ph) front, as George mentioned, they entered into a collaboration with bluebird bio. In connection with the execution of the collaboration agreement, they besides agreed to purchase 420,000 shares of bluebird common stock for $100 million. As section of the agreement, $37 million, the amount paid in excess of the just market value of the shares purchased, will exist credited against their funding responsibility for collaboration research.

    Before I hand the call back to Manisha to commence mp;A, I besides wanted to highlight an exciting announcement Regeneron made in September regarding a modern agreement with the situation of modern York to back economic progress in the Capital Region. Over the next seven years, Regeneron has committed to investing $800 million to expand facilities and create 1,500 modern full-time jobs in modern York State. This expansion will exist supported by $140 million in economic progress incentives from modern York State.

    With that, I would relish to gyrate the call back to Manisha.

    Manisha Narasimhan -- Head of Investor Relations

    Thank you, Bob. John, that concludes their prepared remarks. We'd now relish to open the call for mp;A.

    Questions and Answers:

    Operator

    Thank you. (Operator Instructions) Their first question is from Geoff Meacham from Barclays.

    Greg Harrison -- Barclays -- Analyst

    Hi. This is Greg Harrison on for Geoff. Thanks for taking the question. Can you talk us through the trends you're seeing recently with payer access for Dupixent? believe asthma patients been able to rep access? And how is this prepared -- how is this compared with the launch in atopic dermatitis?

    Marion McCourt -- Senior Vice President and Head of the Commercial organization

    So, certainly, it's early days, Greg, in the launch for asthma. But I can certainly report that, with Dupixent for the modern asthma indication, they are making constant progress, and very pleased with initial dialog with payers. But I'll just remind everyone that this is only their third week in market with the asthma launch.

    Then as a comment, you alluded to atopic dermatitis and payer coverage. Certainly, they view the majority of the market with adequate coverage, and of course, that reflects in the uptake we're seeing with Dupixent performance.

    Manisha Narasimhan -- Head of Investor Relations

    Operator, next question please?

    Operator

    Our next question is from Carter Gould from UBS.

    Carter Gould -- UBS -- Analyst

    Hey, guys. capable morning. Thanks for taking the question. I guess, Len, given entire the commentary coming out of the White House around section B proposals in HHS, just wanted to rep your latest thoughts on sort of that messaging, anything that you guys can attain to either mitigate that front on either on the -- yeah, I'll leave it there.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Yeah. Hi. Thanks for the question, Carter. Obviously, it's tough to know what's going to actually become policy given a lot of these announcements for pre-election. I attain referee the administration is earnest about trying to attain something with drug pricing, but whether or not they'll exist able to rep in a demonstration project, which covers a big fraction of the country, starting the year 2020, with international reference pricing, I referee that's a wide, tremendous open, tremendous question heed at this time.

    Manisha Narasimhan -- Head of Investor Relations

    Next question, please?

    Operator

    Our next question is from Cory Kasimov from JPMorgan.

    Cory Kasimov -- JPMorgan -- Analyst

    Hey, capable morning, guys. Thank you for taking my question. I'm nosy how you're looking at the market occasion for Dupixent in the temper eosinophilic asthma population when considering the low biologic penetration you refer to for ascetic asthmatics to date. So, I guess, given those historic dynamics, attain you referee you'll exist able to penetrate much of the temper patients in the first year or so of the product's launch, or should they really exist focused on severe? Thanks.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    I am going to let Marion reply that question after I just create one brief comment. The market has yet to view a self-administered product. And it is -- penetration is expected to exist exceedingly low for the temper population when you believe to rep to the doctor's office even in an infusion or hang around there for half a day, et cetera, et cetera.

    Marion?

    Marion McCourt -- Senior Vice President and Head of the Commercial organization

    Yeah. So, I'd add to that, that it's not unusual that physicians, and in this case it's pulmonologists and allergists, will often utilize a product, Dupixent in this case, for asthma on some of their tougher patients first. I'll share that, anecdotally, the reports we're getting has been very, very positive. So over time, most definitely, I referee we'll believe success not only with ascetic but besides the temper patients, and I referee that continuum will evolve over market experience. But there are really compelling reasons why and that relates to the clinical profile of Dupixent in asthma, its overall efficacy not only in exacerbations, lung function, OCS reduction and attribute of life, but then besides the broad category of patients that they achieved in their label, moderate-to-severe patients, of course, EOS greater than 150, OCS-dependent regardless of phenotype or EOS.

    As Len mentioned, another ingredient that we're hearing that just so primary is that they are the only asthma biologic to present both at-home, self-administration; and when physicians want to they can always start a patient in the office to assuage educate and train them, but this is a really primary factor in the capacity to believe broader use.

    And then the other item I'd add is that, of course, with Dupixent, we're not launching a modern product, we're launching a modern indication. So allergists who already had flavor with Dupixent, and they already believe shown and established safety profile. So we're really excited about the launch. It's very, very early days. I recognize forward to giving you reports in the future.

    George D. Yancopoulos -- President and Chief Scientific Officer

    And -- this is George. I just want to emphasize about the clinical profile that Marion brought up, which is that, particularly for temper patients, they noiseless can believe pretty substantial reductions in their lung functions. And when you're talking about a biological that maybe the first biological really can believe clinically meaningful impact on lung function, that could really create a unlikeness in patients' lives, and that is some things that has really potential to essentially believe a actual impact on patients' lives. And together with its safety profile, I think, there's a lot of rationale for penetrating into the modern population.

    Manisha Narasimhan -- Head of Investor Relations

    John, next question, please?

    Operator

    Our next question is from Chris Raymond from Piper Jaffray.

    Chris Raymond -- Piper Jaffray -- Analyst

    Hey, thanks. Just a question on the Dupixent peanut allergy study or travail that you're doing with Aimmune. Can you maybe talk about a diminutive bit in detail the objectives of this work, maybe the strategy even? I referee you've talked about being able to potentially ameliorate on Aimmune's flavor in desensitizing kids during the up-dosing period, but can may exist just frame for us what is -- there's obviously a lot of occasion in food allergy not just peanut allergy, what does success recognize relish from this initial trial? And where attain you referee that could buy you in terms of sort of penetrating that other market, that bigger market? Thanks.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Just to rep into the science for a second, I referee that everybody has to understand that the judgement you believe allergies is you believe a unavoidable benign of immunoglobulin known as immunoglobulin E that is bound to the surface of mast cells and basophils. And once it interacts with allergen, it clusters on the surface of these cells, resulting in degranulation release of histamine and other allergic mediators. That's the fundamental basis of allergy. For those of you who don't know, interleukin-4 and interleukin-13 are the IgE switch factors.

    When you try desensitization therapy, the entire goal of that therapy fundamentally is to reprogram the immune system and create the immune system create capable antibody, or immunoglobulin G, as in George, instead of immunoglobulin E, as in Ellen. So -- and when you are trying decentralization, you don't really believe a natural course of actually impacting whether the cells that are involved in the response travel to IgG or IgE. IL-4 blockade and IL-13 blockade are the fundamental drivers. So, in any setting of desensitization, giving Dupixent should attain or drive exactly the benign of reprogram that you want, that historically has been very difficult to achieve. And in animal studies, the results are pretty much black and white.

    So they believe that in almost any setting of desensitization, whether it exist peanut, grass, whether it exist with any approach, the entire goal is to halt making IgE into to start making IgG, that is exactly what Dupixent can do. So (inaudible) success in that study is faster capacity to tolerate higher doses of the peanut during the entire desensitization, diminish the number of patients who believe allergy-mediated side effects, mostly GI side effects that circumscribe their capacity to buy or linger on the treatment. entire these will exist indicators that Dupixent is doing exactly what they referee it should exist doing, which is driving more IgG and preventing the corpse from making the IgE, and thus, reprogram corpse away from allergy. And this is just the beginning. If it works in peanut, it has a signal here, it should exist applicable to essentially every figure of desensitization available by whatever modality.

    Manisha Narasimhan -- Head of Investor Relations

    Operator, next question, please?

    Operator

    Our next question is from Geoffrey Porges from Leerink.

    Geoffrey Porges -- Leerink Partners -- Analyst

    Thank you very much for taking the question. Just to ensue up Dupixent a diminutive bit. Could you just address the question of the adolescent indication and what your expectations are there? And you mentioned the population, but would you await adoption to exist faster or slower there?

    And then just back to the asthma launch. Could you remark on whether you referee this is going to exist actively managed by payers, whether they'll exist step edits and rebates involved or attain you referee that you're largely going to sort of exist able to price more or less at the selfsame price as you believe in IgE and believe unrestricted access? Thanks.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Geoff, before Marion answers, they invite you to approach by, they might believe a antiviral antibody they can give you.

    Geoffrey Porges -- Leerink Partners -- Analyst

    I'd appreciate that. (multiple speakers)

    Marion McCourt -- Senior Vice President and Head of the Commercial organization

    So, Geoff, addressing your comments first on Dupixent uptake in adolescence. Well, as mentioned, they very much recognize forward to the indication in helping this group of patients with moderate-to-severe disease and the agonies that goes with that for both them and their families. They would anticipate that the uptake should exist on similar to potentially a bit faster than what they saw in adult atopic dermatitis, and I referee it's for two reasons. I want to exist a diminutive conservative in motto similar but the judgement why I referee realistically it might exist a diminutive bit faster to these patients is that physicians now believe experienced the Dupixent, and the product is becoming well known, depth of prescribing is increasing. And for that reason, coupled with the fact that this is an alarming disease for adolescents, they believe it's very primary that they rep the word out quickly, and there's mighty excitement and enthusiasm in the market for this indication for this proven patients who are truly suffering.

    Your second question related to asthma and payer uptake. It's very early days. This is their third week of launch. So, things are going well. There's been mighty receptivity to the clinical profile of the product, but I referee I'd rather approach back and give more detail on payer specificity as they believe more time in market.

    Geoffrey Porges -- Leerink Partners -- Analyst

    Great. Thanks very much.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    I just wanted to add to the pediatric side of this is that in that setting, steroids, whether they're absorbed from (inaudible) or with systemic verse of treatment in adolescence during the growth spurts is a tremendous deal. So, I referee that's another judgement why doctors might want to whisk to early adoption.

    Manisha Narasimhan -- Head of Investor Relations

    Next question, please?

    Operator

    Our next question is from Matthew Luchini from BMO Capital.

    Matthew Luchini -- BMO Capital Markets -- Analyst

    Hi. Great. Thanks for taking the question. Just on Dupixent. We've had the DTC push ongoing now for a diminutive while. I was wondering if you could give us an update or your latest view on the patient amalgamate that's currently receiving the drug for atopic dermatitis, as well as perhaps your view on current persistence or refill rates. That's something that I don't referee was mentioned in the earlier remarks. Thank you.

    Marion McCourt -- Senior Vice President and Head of the Commercial organization

    Sure. So let me buy persistence and refill rates first. So the persistency that we've commented on in the past at the 12-month point being approximately 80% continues. So they view sturdy persistency with Dupixent. Similarly, on the first script, refill is an primary factor. They noiseless view that at over 90%. So these are indicators that when patients travel on Dupixent therapy for atopic dermatitis, they want to linger on therapy because their lives are better.

    The second piece you mentioned is a diminutive bit on the DTC, I believe, was section of the question, and besides the types of patients. So, similar to the remark I made before, it's not unusual for physicians to start with their most ascetic patients, but clearly now we're getting penetration not only with ascetic but besides temper patients. And they really thought it was section of their responsibility to -- for this disease and for patients who potentially previously had given up because therapies were not really helping them at all, they thought that this product was absolutely model for an on-air branded campaign. We're noiseless only in months of that branded Dupixent TV campaign. It was preceded, as some would recall, by a disease awareness push and they thought that was the right order to attain things. We've been in national broadcast mode with the Dupixent TV push now since about the August time frame. So we're several months in. The signs they view so far are encouraging.

    Manisha Narasimhan -- Head of Investor Relations

    Next question, please?

    Operator

    Our next question is from Terence Flynn from Goldman Sachs.

    Terence Flynn -- Goldman Sachs -- Analyst

    Hi. Thanks for taking the question. No, you are unlikely to give EYLEA guidance for 2019, but maybe you could just talk about the puts and takes heading into next year. It looks relish we're on track for another double-digit year of branded growth here. So just wondering if they referee that should continue heading into '19. And then you mentioned this higher dose formulation of EYLEA. Maybe what believe you learned that drove this decision, and what would actually exist required to bring that to market? Thanks.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    So maybe George can buy the higher dose and then they can remark about the market.

    George D. Yancopoulos -- President and Chief Scientific Officer

    Well, in terms of the higher dose, I guess the point is that they remain impressed with the fact that EYLEA has stood up with so much competition in that no one has really been able to approach up, seemingly, with a fundamentally different profile in terms of benefit, effects on vision or duration of treatment. And so they thought that it was time, especially because we've been working on this in the labs for a while to view whether just giving a higher dose of EYLEA can actually buy EYLEA has what is now, they think, the gold yardstick in the domain and view if they could either ameliorate the benefit and/or extend the duration of the interval. And so we're poised, we've been working on this for a while and we're going to exist putting in the clinic this year.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Next year, 2019.

    George D. Yancopoulos -- President and Chief Scientific Officer

    Sorry, 2019. Yeah.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Right. So -- and in terms --

    George D. Yancopoulos -- President and Chief Scientific Officer

    I'm already operating in 2019.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    In terms of the market growth, they view nothing that would change the underlying demographics for the enlarge in diabetes and the enlarge in AMD, continuing to grow the market somewhere in the mid- to high- or low-double digit growth over time. Those demographics attain not appear to exist letting up at all. Obviously where they proper in there, based on competition what believe you, we'll believe to view how that plays out. But I reecho George says, they haven't seen anything that's disruptive. They certainly haven't seen a drug, even the most touted drug by the sponsor RTH. It seems to me, they believe forgotten that the retinal specialists are actually some of the smartest guys out there is physicians, and they can attain math and they can multiply 75% times about 50% and approach up with a lot lower number than 75%. So, it seems to me that EYLEA has a really capable profile.

    In addition, what they saw in the diabetic retinopathy studies was, they think, quite remarkable. I referee it was startling to many how frequent it was that people untreated with asymptomatic diabetic retinopathy given placebo just watch for a year and what a big fraction of them, about a third, actually developed vision threatening complications, and this can exist dramatically prevented and reduced. Not only ameliorate the diabetic retinopathy but preclude the progression of the diabetic retinopathy. And they referee that that's a tremendous deal. It's going to buy some reeducation out there of both patients and physicians, but they referee that's a fundamental advance. recall that diabetes and diabetic eye disease is one of the leading noiseless causes -- leading cause of blindness in adults.

    Manisha Narasimhan -- Head of Investor Relations

    Operator, they believe time for one terminal question, please.

    Operator

    And their terminal question is from Ying Huang from Bank of America.

    Ying Huang -- Bank of America Merrill Lynch -- Analyst

    Hi. Thanks for taking the question. I believe one for NGF. In the recently released aspect 3 top line, you saw the placebo adjusted rate of adjudicated arthropathy at about 2%, and then they saw the Pfizer tanezumab at ACR showed less than 1.5% incidence of RPOA. Just wondering whether you referee this benign of safety is acceptable for the FDA and for the treating physicians, and what's the gating factor for the long-term safety in your aspect 3 trial.

    And then next, if you could give us diminutive bit more color on the collaboration with bluebird, exactly what benign of target, what benign of therapy you're focusing on. Thank you.

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    Thanks, Ying. Let me just remark on the fasinumab and then maybe George can remark on bluebird or add to fasinumab. But I believe to whisper that I referee they know that in any drug dosing, any drug progress program, getting the dose right is really, really important, and that becomes super primary when you believe a very abrupt dose response curve for side effects. And they referee that their approach has been to really try and rep that dose right and they are hopeful that the very low dose that they got that is noiseless able to bear what's basically so far at least best-in-class efficacy results and (inaudible) cross-study comparisons and entire that, but really capable efficacy results thus far. But perhaps, as George said in his prepared remarks, mitigating the safety.

    In terms of safety, I don't referee it's just going to exist the adjudicated arthropathies, which -- that probably would exist in acceptable level. But I besides referee there's a question of whether or not these event -- this treatment will lead to more or less joint replacements. There is some evidence, I believe you'd (ph) believe seen in the other progress program, certainly in hours at higher doses that you would view more joint placements, and that probably would not exist acceptable. Their program is very carefully monitored by an independent VSMB (ph) which is met recently and advises to continue progress at these low doses where we've demonstrated the efficacy. So they hope that we've got the dose right. Being first here may not exist nearly as primary as being right, because there's not as much margin for mistake in this program as there might exist in others.

    George can talk about bluebird.

    George D. Yancopoulos -- President and Chief Scientific Officer

    Just to add to that, as you know, they are continuing their long-term safety study with NGF. And Len said, I mean, the most primary data is to view what the benefit will exist compared to adverse events with they believe at this point since they appear to believe mitigated against at least the arthropathies. The total joint replacements numbers are going to exist very primary certainly with the competitors program that is a concern. And we'll believe to view whether their dose gets around that.

    In terms of bluebird, I think, for us, it's a very exciting collaboration. Clearly, they've demonstrated and they've developed their technologies and abilities to develop these CAR T therapies. What they bring to the table is, they bring modern targets and modern reagents, whether they exist antibodies or T-cell receptor related reagents that can target modern targets that can exist reserve into and made into chimeric antigen receptors by bluebird to exist reserve into their cells and used via their therapeutic approach. So we're very excited about putting together their capacity to bring modern targets and modern ways to create these chimeric antigen receptors together with their capacity to buy those forward and deliver them to patients and they referee this is a actual synergistic collaboration between two companies with very complementary capabilities, and we're hoping to exist able to change the future there.

    Ying Huang -- Bank of America Merrill Lynch -- Analyst

    Thank you.

    Manisha Narasimhan -- Head of Investor Relations

    Thank you, George. Operator, that concludes their prepared -- their call today. I know they weren't able to rep through entire your questions, but tickle ship me an email and they will schedule a follow-up call with you.

    Operator

    Thank you, ladies and gentlemen. This concludes today's conference. Thank you for participating and you may now disconnect.

    Duration: 64 minutes

    Call participants:

    Manisha Narasimhan -- Head of Investor Relations

    Leonard S. Schleifer -- Founder, President and Chief Executive Officer

    George D. Yancopoulos -- President and Chief Scientific Officer

    Marion McCourt -- Senior Vice President and Head of the Commercial organization

    Robert E. Landry -- Senior Vice President, Finance and Chief pecuniary Officer

    Greg Harrison -- Barclays -- Analyst

    Carter Gould -- UBS -- Analyst

    Cory Kasimov -- JPMorgan -- Analyst

    Chris Raymond -- Piper Jaffray -- Analyst

    Geoffrey Porges -- Leerink Partners -- Analyst

    Matthew Luchini -- BMO Capital Markets -- Analyst

    Terence Flynn -- Goldman Sachs -- Analyst

    Ying Huang -- Bank of America Merrill Lynch -- Analyst

    More REGN analysis

    Transcript powered by AlphaStreet

    This article is a transcript of this conference call produced for The Motley Fool. While they strive for their absurd Best, there may exist errors, omissions, or inaccuracies in this transcript. As with entire their articles, The Motley Fool does not assume any responsibility for your utilize of this content, and they strongly encourage you to attain your own research, including listening to the call yourself and reading the company's SEC filings. tickle view their Terms and Conditions for additional details, including their Obligatory Capitalized Disclaimers of Liability.

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