500-205 exam Dumps Source : SP Optical Technology Systems Engineer Representative
Test Code : 500-205
Test designation : SP Optical Technology Systems Engineer Representative
Vendor designation : Cisco
: 50 existent Questions
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Cisco remains on the innovative, using optical industry innovation for their consumers. these days, I’m restful to proclaim that we've carried out the rating of Optical network Market leader in the 2018 IHS Markit technology supplier Scorecard.
mainly, the record states that Cisco leads the box this yr in market partake momentum with NCS a thousand earnings to the net-scale neighborhood, mixed with the start of the Verizon 100G metro-packet optical project.
The only file of its variety, this Scorecard evaluates the desirable optical community gear carriers on standards the usage of concrete records and metrics, together with direct comments from patrons, dealer market share, market partake momentum, financials, manufacturer recognition, popularity for innovation, and other benchmarks. This strategy eliminates subjectivity and ensures companies are assessed accurately and relatively.
day after day they set out to clear up their shoppers’ excellent challenges. i would enjoy to thank their clients and partners for your endured partnership – you champion gas their obligate to proceed traffic disruption and innovation. I furthermore lengthen congratulations to the Cisco Optical techniques group and admire their complicated drudgery in incomes this tall difference.
study more about Cisco’s newest improvements on their Optical Networking website.
(Corrects income pattern to $12.45 billion and estimates to $12.41 billion in paragraph three)
Feb 13 (Reuters) - Cisco methods Inc reported second-quarter income that beat Wall highway estimates on Wednesday, because the community apparatus maker benefited from its shift to newer companies comparable to software application and cyber security.
The traffic mentioned web revenue of $2.eight billion, or 63 cents per share, in its quarter ended Jan. 26, in comparison with a loss of $eight.seventy eight billion, or $1.78 per share, a 12 months prior, when it took a freight of $eleven.1 billion concerning the unique U.S. tax legal guidelines.
total salary rose four.7 % to $12.45 billion. Analysts on typical had expected income of $12.41 billion, in keeping with IBES statistics from Refinitiv. (Reporting by Arjun Panchadar in Bengaluru; enhancing via Anil D’Silva)
in keeping with Bloomberg, Cisco methods CSCO is in talks to purchase Luxtera Inc., an optical chip technology enterprise, for an undisclosed quantity.
Per sources customary with the count, the deal may well live worth lots of of thousands and thousands of greenbacks. based on reviews, Cisco became the winner, beating the friends Intel Corp. INTC and Broadcom Inc. AVGO, in the bid to purchase Luxtera.
besides the fact that children, details are scarce at this ingredient because neither party turned into obtainable for comment. chiefly, it’s even workable that the buyout agreement may not even materialize.
Headquartered in Carlsbad, CA, Luxtera’s silicon photonics know-how offers excessive velocity of information transfer across video streaming, cloud and mobile. The deal will assist Cisco add extra primary technology to its open-supply application with the goal to construct networking equipment.
Coming to the expense performance, shares of Cisco abide again 23.4% in a 12 months, outperforming the business’s rally of 20.5%.
Synergies from Buyout
the mixing of Luxtera’s silicon photonics expertise with Cisco’s community and cloud security platforms is probably going to further boost protection facets and assist the latter beget extra differentiated items, thereby mitigating phishing incidents on devices. This acquisition will assist Cisco to convey on its commitment of safeguarding customer data while focusing on americans-centric cozy commercial enterprise IT approach.
With this buyout, Cisco’s consumers should live in a position to adventure more desirable flexibility in operations, superior multi-stage protection, multiplied awareness and more desirable administrative control.
Cloud know-how is being increasingly adopted throughout agencies to innovate, deal with greater volumes of sensitive records, proffer protection to towards cyber-safety threats and power boom. This merger will champion each the businesses leverage each and every different’s materials to create an creative enterprise model and beget the environment more relaxed.
over the final few years, strategic acquisitions abide played a crucial position in shaping Cisco’s increase trajectory. The enterprise closed the acquisition of conduct for $270 million and privately-held Duo security for $2.35 billion in cash.
Cisco additionally announced its plans to purchase Burlingame, CA-primarily based July systems. Cisco is neatly poised to leverage the modern know-how at a lot of stages of its operations and gain a aggressive side.
continuous strategic acquisitions should soundless lead Cisco in expanding its product offerings, strengthening footprint within the security markets and pile client base. further, these acquisitions pomp the company’s goal to raise its application and service capabilities as a pass to diversify salary streams to beget it extra habitual in nature. it's taking this initiative to mitigate the cyclicality linked to hardware revenue.
youngsters, these acquisitions are more likely to retain Cisco’s operating margins under pressure, because it requires giant volume of unique investments.
Zacks Rank and shares to accept as True with
presently, Cisco contains a Zacks Rank #3 (hang).
a better-ranked stock in the broader know-how sector is Twitter, Inc. TWTR, wearing a Zacks Rank #1 (powerful purchase). that you may contemplate the comprehensive record of nowadays’s Zacks #1 Rank stocks prerogative here.
Twitter has long-term expected profits growth fee of 22.1%.
looking for shares with Skyrocketing Upside?
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Freeze drying is a long and expensive fill/finish operation that is required for many pharmaceutical and biotechnology products to ensure product stability, efficacy and long shelf life prior to distribution to patients.
One of the key parameters affecting product property is residual moisture (RM) content. The RM is typically lowered to a flush that will no longer champion chemical reactions (or biological growth).
RM is lowered to control chemical and physical degradation processes. Although most drug products are dried to RM values of <1%, some of the unique biotechnology products may require an intermediate RM value, 2-5%, to maximize product stability, safety and efficacy.
Despite the import of RM, there is currently no real-time monitor capable of determining RM throughout the secondary drying aspect of lyophilization.What outcome would too much, or too microscopic water abide on a finished pharmaceutical product?
The outcome of residual moisture on product stability has been studied for numerous products. In most cases lower levels of residual water improves stability and the manufacturer needs to poise increased drying times that result in lower water levels with a reduction in process efficiency and additional processing complications to achieve and maintain the extremely low levels of residual moisture.
In some cases, lower levels of residual water can lead to a reduction in product stability, specifically for protein-based products and vaccines. It has been reported that a minimum flush of residual water is required for conformational stability and over-drying can lead to a loss in product property and stability.What does Physical Sciences Inc. proffer to monitor and manage water removal?
Physical Sciences Inc. has developed a Tunable Diode Laser Absorption Spectroscopy (TDLAS) based water vapor mass current rate monitor, called the LyoFlux®, that provides continuous measurements of the water removal rate during pharmaceutical freeze-drying operations.
The sensor uses a non-intrusive, near IR optical absorption technique to monitor the water vapor concentration and gas current velocity in the duct connecting the lyophilizer product chamber and condenser.
These measurements are used in combination with the duct cross-sectional district to compute the instantaneous water vapor mass current rate (grams/second) in the duct. These measurements can live integrated to provide a continuous, real-time determination of the total amount of water removed during the freeze-drying process.
We note that the determination of product RM is a microscopic harder to determine. The End user cannot simply subtract the integrated TDLAS measurements of water removed during freeze-drying from the total amount of water added to the batch of vials undergoing freeze-drying.
This is because the total solid content of the formulations is typically in the 5% - 10% range. Measuring RM of the remaining solid following drying would require a measurement mistake of 0.05% - 0.1% for a product RM content of 1%.
This is beyond the capability of the TDLAS sensor, and in fact most analytical instruments. In collaboration with the University of Connecticut, TDLAS-based determination of RM has been demonstrated based on correlating the TDLAS measured water vapor concentration at the End of primary drying to Karl Fisher based RM measurements.
The evolution of the correlation curve for a specific product is performed once in a laboratory scale freeze-dryer and then has been used for subsequent laboratory and pilot scale experiments. This correlation curve essentially erases the measurement mistake accumulated during primary drying and enables accurate integration of the measurements during secondary drying to foretell product RM throughout secondary drying with a useful measurement accuracy of +/-0.5%.What features does PSI proffer to ensure a reliable freeze-drying process?
The LyoFlux® sensor provides real-time data that can live used to efficiently develop and monitor freeze drying processes. use of the sensor helps process engineers reclaim time and money in developing their cycles and supports rapid disposition of product by production engineers following a process disruption.
PSI, through a long and productive collaboration with the University of Connecticut, has demonstrated numerous applications of the LyoFlux® technology for monitoring freeze-drying processes including the determination of:
Many of the pharmaceutical industry End users abide furthermore demonstrated these measurements and additional applications of the technology, including the evolution of property by Design (QbD) erudition and design spaces.
Back in the late 1990’s and early 2000’s a couple of vital papers were published that demonstrated that through the use of gravimetric determinations of mass current and the well-accepted equable condition model of heat and mass transfer of vial-based freeze-drying, a product, vial and dryer specific process design space could live calculated and graphically displayed that provided lyophilization process engineers with a comprehensive overview of the drying process.
This approach calculated shelf and product temperature isotherms of the water vapor mass current rate as a role of process pressure. When combined with the erudition of the gear capability limit, furthermore displayed as mass current as a role of process pressure, the graphical output provided a QbD based system of developing the lyophilization process design. In addition, the process engineer could foretell how the product temperature would respond to workable process shocks in pressure and shelf temperature.
The only problem with the gravimetric based approach was that the data required to compute the erudition and design spaces would require weeks to months to obtain. That is because gravimetric based experiments required for the data collection had to live race in equable state.
These data were used to determine the key parameters including the pressure matter values of Kv, the continuously changing value of Rp (as a role of dehydrate layer thickness) and the pressure matter gear capability limits.
Use of the TDLAS sensor to acquire the identical data means that experiments no longer had to live race at a fixed set of conditions (e.g. pressure) and this shortened the data collection term to approximately 1-2 weeks. The use of the TDLAS sensor to develop the process design space will abide the highest impact on pharmaceutical freeze-drying process development.The LyoFlux sensor from PSI are furthermore available to live fitted into SP Scientific freeze-dryers, please give an overview of your partnership and how this collaboration helps both companies remain at the cutting edge of freeze-drying.
PSI has had a relationship with SP Scientific from the initial experiments that demonstrated the feasibility of the TDLAS measurements in a Lyostar 2 freeze dryer back in 2004. During the past ~5-years, this relationship has been strengthened and is now producing product improvements and unique products that directly profit their pharmaceutical customers.
This collaboration has enabled efficient application of the TDLAS technology to different scale lyophilizers, such as the miniature LyoCapsule and the larger LyoConstellation S20 pilot scale dryer.
We abide successfully demonstrated accurate mass current measurements and importantly, accurate determinations of batch unconcerned product temperatures when the mass current measurements were combined with the heat and mass transfer model of freeze drying. Thus, these tools enable more rapid process evolution and scale-up, ultimately allowing End users to streamline their processes and salvage their products to the market faster.
A key improvement has been the evolution of software that allows direct communication between the freeze-dryer and the TDLAS sensor. This communication provides the sensor with continuous measurements of the freeze dryer product chamber pressure, shelf temperature and the product temperature data.
The pressure and shelf temperature values provided to the sensor remove the requisite for user inputs to the sensor throughout the lyophilization process and allow truly autonomous operation of the sensor 24/7/365. This is a tall profit to the End user, saving time, resulting in fewer data collection errors and providing a sole location for capturing and plotting the process data for subsequent analysis.
Process recipes are input into the dryer and the user initiates the freeze-drying cycle, from this point the process runs without operator intervention to apply this technology. At the confiscate times in the process the dryer opens and closes the isolation valve to determine measurement offset values and initiates sensor integration of the mass current measurements.
The TDLAS sensor measurements and totality of the resulting heat and mass transfer model data products calculated using the sensor and freeze dryer data are transferred to the lyophilizer control computer for storage using the dryer data historian. This ensures a common time stamp for totality of the data and easier pomp and processing by the End user.
The collaboration between SP Scientific and PSI keeps us both at the cutting edge of freeze-drying technology by allowing us to drudgery together on research and evolution projects. The establishment of communication (and control) between the sensor and the freeze-dryer has furthermore provided the foundation for more advanced applications of the sensor technology. PSI and SP Scientific recently completed a collaborative R&D application that has created the TDLAS SMART Freeze Dryer technology.
The TDLAS SMART FD enables the evolution of a freeze-drying cycle using a sole experiment. It combines the existing Manometric Temperature Measurement (MTM) based SMART algorithm with TDLAS determinations of the water vapor mass current to create a unique product that overcomes the limitations of the original MTM based product.
The SMART™ freeze drying technology automatically generates a freeze-drying cycle based on user inputs of product characteristics and vial dimensions, combined with non-intrusive TDLAS-based in-process product temperature measurements and a pseudo-steady condition heat and mass transfer model of freeze drying in vials.
This evolution enables the application of the SMART FD technology for a much wider range of product formulations, including high weight percentage amorphous biological products, on both laboratory and pilot scale freeze dryers, supporting both process evolution and scale-up.
PSI and SP Scientific continue to explore additional applications and automation of cycle evolution with the ultimate goal of sensor-based cycle control. They recognize that automated cycle control will require many years of additional R&D and industry testing, but achievement of this goal is directly in-line with the FDA Process Analytical Technology (PAT) and property by Design (QbD) initiatives.What features champion your customers in increasing their understanding and robustness of the routine freeze-drying process?
The recent evolution and rollout of sensor and freeze dryer software packages enable direct communication and control between the sensor and the lyophilizer are vital improvements for their customers. The communication (and control) capability significantly improves user application of the sensor technology, reducing the potential for end-user errors in applying the LyoFlux® sensor.
The data sharing between the two systems furthermore enables real-time and accurate calculation of the heat and mass transfer model data products and storage of the data on the freeze-dryer. Their goal is to eventually liquidate the sensor user interface, preparing the combined system for application in a manufacturing environment.
This will provide End users with a moneyed library of data for each batch of the product that is freeze-dried. Currently these existent time data sets provide process evolution scientists with the information needed to increase their understanding of the drying process, life cycle management, and enable evolution of robust processes using property by Design principles. In the future this data will live available to enable more rapid release of lyophilized product and more rapid disposition of product following process deviations.How does the TDLAS sensor integrate with other freeze dryer scales in the manufacturing process to ensure a smart approach to production and a reliable property of the product?
The LyoFlux® sensor is applicable to totality size freeze dryers as long as they can insert an optical spool in between the freeze dryer product chamber and the condenser. PSI has demonstrated application on dryers ranging from the SP Scientific LyoCapsule® miniature, seven, 20mL vial lyophilizer, which has a 2-inch spool, up to a manufacturing scale lyophilizer which has a 30-inch diameter spool.
The sensor control electronics, data acquisition and processing algorithm are common for totality size dryers. A fiber optic and electronic signal umbilical cable connects the sensor control unit to the freeze dryer optical spool.
A common optical platform is used for totality spools, thus the only change with dryer scale is the size of the spool and the location of the optical ports. Because they are using absorption spectroscopy, longer absorption pathlengths associated with larger spools provide higher signal to uproar ratios.
To date their most common installation has been on the SP Scientific Lyostar 3 laboratory scale freeze-dryer, but they abide fielded many recent inquiries for potential installations on larger dryers.
We believe that this indicates a natural evolution of the product application from the laboratory to manufacturing scale. It may live occurring at this time due to widespread industrial erudition of the technology and the numerous publications describing application of the sensor, including a publication by the FDA.
Companies that adopt the LyoFlux® technology for monitoring their processes on totality scale freeze dryers will abide common data sets from evolution through scale-up to manufacturing. This should result in improved process understanding, likely faster time to market and more efficient assessment of product property in the event of process disruptions.What’s next for Physical Sciences Inc?
Physical Sciences Inc. continues to drudgery with both their academic and industrial collaborators to develop next generation sensors, and to better application of the TDLAS technology, with the eventual goal of using the LyoFlux® sensor and other PAT sensors for real-time process control.
PSI is currently collaborating with university and industrial partners to apply the TDLAS technology and process models for improved lyophilization process evolution and scale-up. This includes the evolution of a unique aseptic, pilot scale lyophilization facility to enable testing of unique sensors and process evolution models in an environment that is representative of a manufacturing facility.
This will champion the pharmaceutical industry and the training of the next generation scientists and process engineers on lyophilization process evolution and scale-up. This facility, which is expected to near on-line in drop 2019, will live available as a user facility to both academia and industry. In summary, they are soundless actively pursuing numerous R&D projects to promote the sensor and its application.Where can users find more information? About Bill Kessler
Bill Kessler received his undergraduate and graduate degrees in chemistry from Boston University, performing ultra-high-resolution gas spectroscopy. His research focused upon multi-photon excitation of aligned ionic states.
In 1986 Bill joined Physical Sciences Inc. in Andover, Massachusetts as a staff scientist. His drudgery at PSI has spanned numerous disciplines including combustion, atmospheric, and chemical laser research. Bill’s focus shifted to the evolution of diode laser-based sensors and sensor networks which leveraged the tools created by the optical telecommunication industry for industrial sensor applications.
In December 2000 Bill became a founding member of the PSI-spinout company, Confluent Photonics Corp., focused on developing high index contrast optical waveguides for optical telecommunications. Bill served as the Director of Applications Engineering while at CPC and its partner, the MIT Lincoln Laboratory, developed silicon-on-insulator waveguide tapers for efficient laser source coupling to sole mode photonic circuits.
He returned to PSI to pursue the evolution and application of advanced optical sensors for pharmaceutical process monitoring and control. Bill is now the Vice President of the Applied Optics traffic enterprise within PSI and is the technical lead for the tunable diode laser absorption spectroscopy based LyoFlux® product. He oversees two additional traffic units, the Biomedical Optics Technology and Aerothermal System groups.
Contact information: [email protected], 978-738-8253
Spectral Domain-OCT is the most attractive segment in the global optical coherence tomography market with an attractiveness index of 2.9 over the forecast period
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Valley Cottage, NY -- (SBWIRE) -- 02/15/2019 -- A significant surge in the episode of cardiovascular and ophthalmologic disorders has been recorded in recent years. As a countermeasure, condition authorities and private organisations in ophthalmic care are introducing several eye care programs for the general public. Globally, the number of people with eye disorders has increased to a austere level, hence further escalating the requisite for advanced eye care imaging and treatment. This has been observed as a major factor fuelling the require for optical coherence tomography of late.
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A unique study conducted by Future Market Insights (FMI) reveals that the global optical coherence tomography market to grow from US$ 660.5 Mn in 2016 to US$ 1,349.1 Mn by 2027-end. This market is expected to expand at a CAGR of 6.7% in terms of revenue between 2017 and 2027. During this ten years of the forecast, the popularity of optical coherence tomography is expected to grow rapidly as medical companies are laying stout accent on evolution of portable devices in order to increase the adoption rate of such imaging technology.
Global Optical Coherence Tomography Market: Opportunities and Trends
Manufacturers of OCT systems are actively focusing on expanding their existing range of products. Some of the latest OCT systems now near with multi layers analysis of the surface as well as proffer higher image resolutions. Moreover, making such systems portable and user-friendly is anticipated to inspirit their robust adoption in the near future. Also, players in the global market for optical coherence tomography are expected to profit from increasing medical and non-medical application of OCT.
In an attempt to further better their market position, some of the leading market players are entering into partnership, merger, sales agreement and acquisition with local manufacturers from emerging countries. FMI in its report titled "Optical Coherence Tomography Market: Global Industry Analysis and chance Assessment, 2017–2027" has profiled leading market players such as Leica Microsystems (Sub. Danaher), Optovue Inc., Carl Zeiss Meditec AG, Santec Corporation, Heidelberg Engineering GmbH, OPTOPOL Technology Sp. z o.o. (Sub. Canon Inc.), Topcon Corporation, Michelson Diagnostics Ltd, Tomophase Inc., Moptim Imaging Technique, NIDEK CO., LTD., Sonostar Technologies Co., Limited.
Additional Highlights of the Report Include:
Preference for spectral domain-OCT is projected to remain relatively higher as compared to other types of OCT throughout the forecast period.
Application of OCT in ophthalmology is expected to bring in US$ 983.4 Mn in revenues towards the End of 2027.
Based on End users, hospitals are estimated to account for more than 39% market partake over the assessment period.
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Among regions, North America is expected to hold the largest partake of the market during the forecast period. By 2017-end, the region's market is expected to achieve a valuation of US$ 232.2 Mn. Meanwhile, the OCT market in Asia-Pacific excluding Japan is expected to witness the highest growth over 2027. Owing to this, a number of leading market players such as Carl Zeiss Meditec AG, Topcon Corporation and Heidelberg Engineering GmbH are increasing their penetration in some of the key countries in the region, especially in China with their high-quality product types and services.
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San Francisco biotechnology company Prellis Biologics, has reported record speeds in tissue 3D printing using its holographic technology.
According to Dr. Melanie Matheu, co-founder and CEO of the company, “A major goal in tissue engineering is to create viable human organs, but nobody could print tissue with the quicken and resolution needed to shape viable capillaries,”
“At Prellis, we’ve now developed that technology, paving the pass for vital medical advances and, ultimately, functional organ replacements.”
3D printing capillary structure using Prellis Biologics’ holographic technology. Image via Prellis Biologics
Holographic 3D bioprinting
3D printing at Prellis is performed by a laser-based process capable of curing liquid to solid in under less than 5 milliseconds of exposure time.
The technology is used to 3D print fine capillaries, that deliver nutrients to cells, and scaffolds, that champion support the growth of cells into a 3D tissue.
Instead of post-seeding the scaffolds and capillaries with cells, the live matter is actually mixed into the print material. To avoid any cell damage due to light exposure, Prellis uses a far-red laser light to cure the material.
“A kidney in 12 hours or less”
The key benefits of the Prellis process are that it 3D prints at a high resolution, (producing feature sizes as little as 0.5 microns) and high speed, accounting for the rapid deterioration of live cells, which would die in less than 30 minutes without nutrients.
Dr. Matheu explains “The quicken they can achieve is limited only by the configuration of the optical system. They are now exploring custom optical system development, which will dramatically increase their capabilities,”
“Our ultimate goal is to print the entire vascular system of a kidney in 12 hours or less.”Prellis Biologics engineer studies 3D pritned tissue under a microscope. Photo via Bussiness Wire
Towards a fully 3D printed organ
The kidney has become a significant district of interest in 3D bioprinting research. In particular, much application has been placed in recreating the winding proximal tubules – the microscopic veins that beget the foundation of a kidney.
3D biomaterial company Organovo recently published a study demonstrating successful binding of kidney cells to beget a proximal tubule.
And, at Harvard University, Professor Jennifer Lewis’ lab, led efforts to 3D print a proximal tubule “on-a-chip” that can live used for drug testing.
Though insignificant in comparison to a entirely 3D printed organ, research at this stage is providing the pile blocks for future breakthroughs soundless to come.
A white paper assessing the advances and challenges of tissue engineering abide been summarized by Dr. Matheu, and Prellis Biologics’ principle optical engineers Erik Busby and John Borglin here.
Other high quicken laser based 3D bioprinting technologies abide furthermore been explored before. At the University of California, Los Angeles (UCLA), researchers abide developed an SLA based 3D printer that builds multimaterial tissues on a chip.
For medical advances subscribe to the 3D Printing Industry newsletter, ensue us on Twitter, and enjoy us on Facebook.
Search and post 3D Printing Jobs here.
Featured image shows a microscopic 3D printed structure for encapsulating cells. Image via Prellis Biologics
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