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Immunotherapy Advances SCLC medicine panorama | killexams.com existent Questions and Pass4sure dumps

Christine Lee Hann, MD, PhD

Christine Lee Hann, MD, PhD

the novel ordinary of elect trust of the frontline medication of patients with wide-stage little telephone lung melanoma (SCLC) should subsist atezolizumab (Tecentriq) and chemotherapy, according to consequences from the IMpower133 trial, famed Christine Lee Hann, MD, PhD.

This world, randomized section III affliction validated an improvement in survival with the addition of the PD-L1 inhibitor to gauge carboplatin and etoposide in patients with huge-stage SCLC versus the chemotherapy routine alone.

After a median follow-up of 13.9 months, the median universal survival (OS) within the experimental arm changed into 12.3 months compared with 10.three months with chemotherapy solitary (HR, 0.70; 95% CI, 0.54-0.91; P = .0069). Median progression-free survival (PFS) changed into 5.2 months within the atezolizumab arm compared with 4.3 months in the placebo arm.

within the cohort of 403 remedy-naïve patients, everyone sufferers obtained four 21-day cycles of carboplatin AUC 5 mg/mL/min intravenously (IV) on day 1 and a hundred mg/m2 etoposide IV on days 1 via three. sufferers were also randomized 1:1 to acquire both concurrent atezolizumab at 1200 mg IV on day 1 (n = 201) or placebo (n = 202) everyone the course through the induction part. medication become followed with the aid of upkeep therapy with atezolizumab or placebo, in response to the outdated random assignment, every 3 weeks until progressive sickness or loss of clinical advantage.

in addition, single-agent nivolumab (Opdivo) was granted an accelerated FDA approval in August 2018 for the remedy of patients with SCLC with ailment evolution following platinum-based mostly chemotherapy and 1 different line of therapy, marking the first drug approval in this sickness in well-nigh 20 years.

youngsters, other immunotherapy suggestions haven't shown the equal exercise. as an instance, in the side III CheckMate-451 trial, the combination of nivolumab and ipilimumab (Yervoy) did not enrich OS versus placebo as a protection remedy for patients with wide-stage SCLC with out ailment evolution following frontline platinum-based chemotherapy.

In an interview everyone the course through the 2018 OncLive® on the 2018 situation of the Science Summit™ on superior Non–Small phone Lung cancer, Hann, an associate professor of Oncology at Johns Hopkins college of medication, discussed how recent information beget fashioned SCLC remedy.

OncLive: What are the recent advances in SCLC remedy? Hann: probably the most most exciting fresh information emerged at the nineteenth World conference on Lung cancer. Stephen V. Liu, MD, offered outcomes from the IMpower133 examine which evaluated first-line chemotherapy in combination with the PD-L1 inhibitor atezolizumab. This turned into the first study in the frontline setting to exhibit better survival benefit; in fact, there was evolution in PFS and OS in sufferers who obtained the combination. They reckon this can now subsist considered the novel mediocre of elect trust of frontline medicine of this affected person inhabitants. How execute you perceive researchers compounding this statistics for future development? there is a worthy deal to notice forward to. within the final yoke of years, we've had an colossal emergence of records both on the organic discontinuance and on the clinical facet. They withhold in intuition the disease improved and we've discovered novel agents, reminiscent of checkpoint inhibitors, which beget efficacy during this space. The checkpoint inhibitors were effectual in the second-line atmosphere and past.

really, nivolumab bought FDA approval in August 2018 in the third-line setting of SCLC; this turned into the first drug approval they had in 2 many years and it turned into an incredible accomplishment in the box. They are actually combinations and novel molecular targets during this area.

What are some of those rising molecular pursuits and targeted treatments? there has been a renewed pastime in gaining knowledge of SCLC. Consequentially, there has been improved funding from the national melanoma Institute to assist us withhold in intuition the sickness more advantageous. [This renewed interest in SCLC] has emerged in parallel with technological advances that enable us to obtain a deep genomic understanding. They are actually in a position to secure epigenetic and proteomic profiles of the melanoma. within the remaining 5 years, there has been increasing assistance on the proteins expressed in SCLC that may well subsist pursuits.

It is going to elect a very long time to in reality tease through everyone these details, however we're relocating in the correct course. SCLC is a melanoma with a very high tumor mutation burden, so there is doubtless a chore for combined focused remedies.

what's a closing unmet want in SCLC? There had been only a few studies taking a notice at restrained-stage SCLC. whereas there is healing capabilities with chemotherapy and radiation, the substantial majority of sufferers recur locally and distantly. There are reports with immune-checkpoint inhibitors underway in this area, and people [data] could subsist very constructive. With the encouraging information they saw with durvalumab (Imfinzi) in stage III non–small cell lung melanoma, they reckon there is fanciful competencies for previous-line immunotherapy. what's your take-home message to neighborhood oncologists? we beget a novel common of trust for first-line medication of SCLC. numerous reports will also subsist study out within the subsequent yr or so in an effort to expand their armamentarium even further. they are able to perceive statistics presence on the consume of checkpoint inhibitors within the upkeep atmosphere, no matter if [they are being used] in aggregate or as solitary agents. long-term biomarker studies are also standard.

Liu S, Mansfield A, Szczesna S, et al. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung melanoma [published online September 25, 2018]. N Eng J Med. doi: 10.1056/NEJMoa1809064.


Celldex: What's the entire exhilaration About? | killexams.com existent Questions and Pass4sure dumps

No outcomes discovered, are attempting novel keyword!CDX-1127 is an antibody that raises T phone exercise that however a bit differentiated in mechanism of action can subsist compared to the checkpoint inhibitors Yervoy ... had revenue on $1.1 billion in ...

Bristol-Myers Squibb Receives tremendous CHMP belief within the European Union for Opdivo (nivolumab) for the medicine of superior Melanoma in each First-Line and up to now ... | killexams.com existent Questions and Pass4sure dumps

PRINCETON, N.J.--(business WIRE)--Bristol-Myers Squibb industry (NYSE:BMY) nowadays announced that the Committee for Medicinal items for Human consume (CHMP) of the european drugs company (EMA) has adopted a favorable belief recommending that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, subsist granted popularity of consume in both first-line and in the past handled sufferers with advanced (unresectable or metastatic) melanoma. here is the primary high-quality belief given by course of the CHMP for a PD-1 immune checkpoint inhibitor, and it will now subsist reviewed by the eu fee, which has the authority to ratify drugs for the eu Union (ecu).

The EMA granted Bristol-Myers Squibb accelerated evaluation of Opdivo in response to current laws that fulfills its suggestions about “medicinal items of foremost interest from the factor of view of public health and in selected from the view aspect of therapeutic innovation.”

“we are completely satisfied with today’s CHMP fine opinion, as it is a step closer to us bringing this captious drugs for these advanced melanoma sufferers in Europe in want of recent alternate options,” spoke of Michael Giordano, senior vp, Head of construction, Oncology. “Our vision is to seriously change how they fashion melanoma – from scientific practice to greater patient consequences. They continue to expand the breadth and depth of their immuno-oncology portfolio throughout the continuum of melanoma and assorted other cancers, to provide extra sufferers with the talents possibility for long-time term survival.”

wonderful belief according to CheckMate -066, -037

The CHMP wonderful belief is in line with facts from two piece III studies (CheckMate -066 and -037), demonstrating the efficacy and security of Opdivo in advanced melanoma sufferers with vital unmet wants. CheckMate -066, a piece III randomized double-blind examine, evaluating Opdivo to the chemotherapy dacarbazine (DTIC) in sufferers with medication-naïve advanced melanoma, is the primary side III affliction of an investigational PD-1 immune checkpoint inhibitor to demonstrate an conventional survival odds in advanced melanoma, as well as a stronger purpose response rate. A 2d study, CheckMate -037, is a side III randomized, controlled open-label study of Opdivo versus investigator’s alternative chemotherapy in sufferers with advanced melanoma who were up to now handled with Yervoy (ipilimumab), which confirmed evolution in even response rates. These records are supported by means of a side Ib notice at (study -003) in relapsed superior or metastatic melanoma, which validated the first characterization of Opdivo advantage/chance in advanced melanoma. There was consistent Opdivo dosing of 3 mg/kg every two weeks throughout everyone three trials.

About Opdivo

Bristol-Myers Squibb has a huge, global evolution program to anatomize Opdivo in assorted tumor forms along with more than 50 trials – as monotherapy or in mixture with other treatments – in which more than 7,000 patients had been enrolled worldwide.

Opdivo became the primary PD-1 immune checkpoint inhibitor to secure hold of regulatory approval anyplace on this planet on July four, 2014 when Ono Pharmaceutical Co. announced that it acquired manufacturing and advertising approval in Japan for the medicine of patients with unresectable melanoma. within the U.S., the U.S. meals and Drug Administration (FDA) granted its first approval for Opdivo for the remedy of patients with unresectable or metastatic melanoma and disorder evolution following Yervoy (ipilimumab) and, if BRAF V600 mutation effective, a BRAF inhibitor. On March 5, 2015, Opdivo recently received its second FDA approval for the treatment of patients with metastatic squamous non-small mobile lung melanoma (NSCLC) with progression on or after platinum-based mostly chemotherapy.

About superior Melanoma

Melanoma is a kind of skin cancer characterized via the uncontrolled boom of pigment-producing cells (melanocytes) observed in the skin. Metastatic melanoma is the deadliest shape of the disorder, and happens when melanoma spreads beyond the surface of the dermis to the other organs, such because the lymph nodes, lungs, brain or other areas of the physique. The incidence of melanoma has been increasing for as a minimum 30 years. In 2012, an estimated 232,a hundred thirty melanoma circumstances had been diagnosed globally. Melanoma is in common curable when handled in its early ranges. youngsters, in its late stages, the ordinary survival fee has traditionally been simply six months with a one-yr mortality expense of 75%, making it one of the crucial aggressive types of cancer.

Immuno-Oncology at Bristol-Myers Squibb

surgical procedure, radiation, cytotoxic or targeted healing procedures beget represented the mainstay of cancer treatment over the remaining several decades, however lengthy-term survival and a favorable first-class of lifestyles beget remained elusive for a lot of sufferers with advanced disease.

To exploit this unmet scientific need, Bristol-Myers Squibb is main analysis in an innovative box of cancer analysis and medication called immuno-oncology, which includes agents whose primary mechanism is to toil without detain with the body’s immune system to combat cancer. The enterprise is exploring loads of compounds and immunotherapeutic methods for sufferers with several types of melanoma, including learning the potential of mixing immuno-oncology agents that target different and complementary pathways in the remedy of cancer.

Bristol-Myers Squibb is committed to advancing the science of immuno-oncology, with the purpose of changing survival expectations and the course patients are alive with cancer.

about the Bristol-Myers Squibb and Ono Pharmaceutical Collaboration

In 2011, via a collaboration compress with Ono Pharmaceutical, Bristol-Myers Squibb improved its territorial rights to boost and commercialize Opdivo globally apart from in Japan, South Korea and Taiwan, where Ono had retained everyone rights to the compound on the time. On July 23, 2014, Bristol-Myers Squibb and Ono Pharmaceutical additional extended the corporations’ strategic collaboration agreement to jointly boost and commercialize distinctive immunotherapies – as solitary agents and mixture regimens – for sufferers with melanoma in Japan, South Korea and Taiwan.

vital safety suggestions

Immune-Mediated Pneumonitis

  • extreme pneumonitis or interstitial lung disease, including deadly situations, occurred with OPDIVO medication. across the clinical affliction experience in 691 patients with solid tumors, deadly immune-mediated pneumonitis happened in 0.7% (5/691) of patients receiving OPDIVO; no cases happened in affliction 1 or affliction three. In affliction 1, pneumonitis, including interstitial lung disorder, befell in 3.4% (9/268) of sufferers receiving OPDIVO and not one of the 102 patients receiving chemotherapy. Immune-mediated pneumonitis came about in 2.2% (6/268) of patients receiving OPDIVO; one with Grade 3 and 5 with Grade 2. In affliction three, immune-mediated pneumonitis came about in 6% (7/117) of sufferers receiving OPDIVO, including, 5 Grade 3 and two Grade 2 cases. monitor sufferers for indications and signs of pneumonitis. Administer corticosteroids for Grade 2 or greater pneumonitis. completely discontinue OPDIVO for Grade 3 or 4 and withhold OPDIVO unless determination for Grade 2.
  • Immune-Mediated Colitis

  • In affliction 1, diarrhea or colitis passed off in 21% (57/268) of patients receiving OPDIVO and 18% (18/102) of sufferers receiving chemotherapy. Immune-mediated colitis occurred in 2.2% (6/268) of sufferers receiving OPDIVO; 5 with Grade 3 and one with Grade 2. In affliction 3, diarrhea took plot in 21% (24/117) of sufferers receiving OPDIVO. Grade 3 immune-mediated colitis occurred in 0.9% (1/117) of sufferers. panoply screen patients for immune-mediated colitis. Administer corticosteroids for Grade 2 (of greater than 5 days period), three, or 4 colitis. Withhold OPDIVO for Grade 2 or three. completely discontinue OPDIVO for Grade 4 colitis or recurrent colitis upon restarting OPDIVO.
  • Immune-Mediated Hepatitis

  • In affliction 1, there become an accelerated incidence of liver test abnormalities in the OPDIVO-treated group as compared to the chemotherapy-treated group, with increases in AST (28% vs 12%), alkaline phosphatase (22% vs 13%), ALT (sixteen% vs 5%), and complete bilirubin (9% vs 0). Immune-mediated hepatitis took plot in 1.1% (3/268) of patients receiving OPDIVO; two with Grade three and one with Grade 2. In affliction three, the incidences of extended liver check values had been AST (16%), alkaline phosphatase (14%), ALT (12%), and complete bilirubin (2.7%). computer screen patients for abnormal liver checks earlier than and periodically everyone over treatment. Administer corticosteroids for Grade 2 or enhanced transaminase elevations. Withhold OPDIVO for Grade 2 and completely discontinue OPDIVO for Grade 3 or four immune-mediated hepatitis.
  • Immune-Mediated Nephritis and Renal Dysfunction

  • In affliction 1, there turned into an improved incidence of expanded creatinine in the OPDIVO-handled neighborhood as compared to the chemotherapy-treated group (13% vs 9%). Grade 2 or three immune-mediated nephritis or renal dysfunction came about in 0.7% (2/268) of patients. In affliction 3, the incidence of multiplied creatinine turned into 22%. Immune-mediated renal dysfunction (Grade 2) befell in 0.9% (1/117) of sufferers. video panoply sufferers for increased serum creatinine just before and periodically everyone over treatment. For Grade 2 or three serum creatinine elevation, withhold OPDIVO and administer corticosteroids; if worsening or no growth happens, permanently discontinue OPDIVO. Administer corticosteroids for Grade four serum creatinine height and completely discontinue OPDIVO.
  • Immune-Mediated Hypothyroidism and Hyperthyroidism

  • In affliction 1, Grade 1 or 2 hypothyroidism took plot in eight% (21/268) of patients receiving OPDIVO and not anyone of the 102 patients receiving chemotherapy. Grade 1 or 2 hyperthyroidism occurred in three% (8/268) of patients receiving OPDIVO and 1% (1/102) of patients receiving chemotherapy. In affliction three, hypothyroidism passed off in four.3% (5/117) of patients receiving OPDIVO. Hyperthyroidism occurred in 1.7% (2/117) of sufferers, including one Grade 2 case. panoply screen thyroid function prior to and periodically everyone through remedy. Administer hormone substitute therapy for hypothyroidism. initiate medical administration for control of hyperthyroidism.
  • other Immune-Mediated hostile Reactions

  • In affliction 1 and three (n=385), birthright here clinically colossal immune-mediated antagonistic reactions occurred in <2% of OPDIVO-treated patients: adrenal insufficiency, uveitis, pancreatitis, facial and abducens nerve paresis, demyeliniation, autoimmune neuropathy, motor dysfunction, and vasculitis. across scientific trials of OPDIVO administered at doses three mg/kg and 10 mg/kg, extra clinically huge, immune-mediated hostile reactions beget been recognized: hypophysitis, diabetic ketoacidosis, hypopituitarism, Guillain-Barré syndrome, and myasthenic syndrome. based on the severity of adverse reaction, withhold OPDIVO, administer excessive-dose corticosteroids, and, if appropriate, stimulate hormone- substitute therapy.
  • Embryofetal Toxicity

  • in accordance with its mechanism of action, OPDIVO may occasions fetal harm when administered to a pregnant lady. recommend pregnant women of the knowledge risk to a fetus. recommend ladies of reproductive skills to execute consume of valuable contraception everyone over medication with OPDIVO and for at least 5 months after the ultimate dose of OPDIVO.
  • Lactation

  • It is not established even if OPDIVO is present in human milk. as a result of many medicine, together with antibodies, are excreted in human milk and because of the abilities for captious opposed reactions in nursing toddlers from OPDIVO, recommend girls to discontinue breastfeeding throughout medicine.
  • severe opposed Reactions

  • In affliction 1, captious hostile reactions occurred in forty one% of patients receiving OPDIVO. Grade three and 4 opposed reactions came about in forty two% of patients receiving OPDIVO. probably the most habitual Grade 3 and four opposed drug reactions pronounced in 2% to <5% of patients receiving OPDIVO beget been abdominal pain, hyponatremia, multiplied aspartate aminotransferase, and increased lipase.
  • In affliction three, ascetic adversarial reactions occurred in 59% of sufferers receiving OPDIVO. the most regularly occurring captious adverse drug reactions pronounced in ≥2% of sufferers were dyspnea, pneumonia, persistent obstructive pulmonary sickness exacerbation, pneumonitis, hypercalcemia, pleural effusion, hemoptysis, and pain.
  • usual adversarial Reactions

  • essentially the most commonplace adverse reactions (≥20%) mentioned with OPDIVO in affliction 1 had been rash (21%) and in affliction three beget been fatigue (50%), dyspnea (38%), musculoskeletal ache (36%), lowered appetite (35%), cough (32%), nausea (29%), and constipation (24%).
  • Please perceive US plenary Prescribing guidance for OPDIVO.

    About Bristol-Myers Squibb

    Bristol-Myers Squibb is a global pharmaceutical company whose mission is to find, enhance and carry innovative drugs that aid patients subsist triumphant over captious ailments. For more advice about Bristol-Myers Squibb, quest advice from www.bms.com, or comply with us on Twitter at http://twitter.com/bmsnews.

    Bristol-Myers Squibb ahead-looking statement

    This press free up consists of "forward-searching statements" as that term is described within the inner most Securities Litigation Reform Act of 1995 concerning the research, construction and commercialization of pharmaceutical items. Such ahead-looking statements are in keeping with present expectations and accommodate inherent risks and uncertainties, including components that might delay, divert or change any of them, and will trigger actual results and results to vary materially from existing expectations. No forward-looking commentary may also subsist guaranteed. amongst other risks, there can also subsist no guarantee that Opdivo will acquire regulatory approval in the European Union or, if accredited, that it will become a commercially a success product. forward-searching statements during this press free up should subsist evaluated along side the various uncertainties that strike Bristol-Myers Squibb's business, mainly these identified in the cautionary elements discussion in Bristol-Myers Squibb's Annual document on kind 10-okay for the 12 months ended December 31, 2014 in their Quarterly stories on shape 10-Q and their existing reports on kind 8-okay. Bristol-Myers Squibb undertakes no responsibility to publicly update any ahead-searching commentary, whether on account of novel advice, future events or otherwise.


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    156-915-1 exam Dumps Source : Accelerated CCSE 1.1 NGX

    Test Code : 156-915-1
    Test appellation : Accelerated CCSE 1.1 NGX
    Vendor appellation : CheckPoint
    : 272 existent Questions

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    With novel Turing, NVIDIA Doubles Down on the Future of Real-Time Ray-Tracing | killexams.com existent questions and Pass4sure dumps

    18 Oct, 2018 By: Alex Herrera Herrera on Hardware: CAD professionals are expected to harvest the benefits.

    NVIDIA's long-expected successor to its Pascal GPU architecture for gaming and professional graphics is here. In August, the GPU developer pulled the covers off Turing, which one could bicker is both a successor to not one but both of its preceding generations of graphics processing units — 2016's Pascal and 2017's Volta. In the process, the company confirmed several of the more expected 3D graphics advancements for its next flagship GPU. But it also revealed a few surprises, representing an aggressive-but-justified departure from past generations' decisions about how it formulates products that today are destined for a far wider spectrum of applications than those of years past.

    Perhaps even more significant is the inflection point in GPU evolution that Turing marks, a unification — if not permanent and all-encompassing, at the very least meaningful — of the previous disparate and often conflicting priorities between the GPU's traditional 3D graphics markets and the seared emerging opportunities attracting the company's attention. With Turing, NVIDIA confirms two realizations very much reflected in the GPU's DNA: one, that machine learning is now a cogent and justified implement to enhance 3D visual computing; and two, that the time is ripe to open the long-awaited transition from 3D raster graphics to the ultimate in rendering, real-time ray-tracing.

    Turing, RTX, and NGX

    NVIDIA is finding more ways to leverage machine learning to ameliorate performance and property for traditional 3D graphics. It's been a while since NVIDIA shaped novel GPU architectures and technology strictly for the capitalize of traditional raster-based 3D graphics that CAD applications and users beget primarily relied upon. Over the past decade, NVIDIA GPUs beget pushed well beyond that core space and into high-performance computation ("compute"), autonomous vehicles, robotics, supercomputing, and now, front-and-center, machine learning. And each novel generation has walked a careful balance, supporting novel applications without handicapping the GPU for its bread-and-butter 3D graphics markets.

    With Turing, NVIDIA made many of the more conventional improvements to its fundamental 3D graphics programmable shader engine, the Streaming Multiprocessor (SM), especially in terms of captious resources relish chip registers and cache, and dialed up supporting infrastructure including external reminiscence bandwidth — everyone generous things that contribute to faster, higher-quality interactive 3D graphics crucial to improving the CAD experience and productivity. But those tweaks depict the more expected steps along the tried-and-true GPU evolution path, taking on cost and complexity for features and performance the company is pretty darn confident ISVs and discontinuance users alike will value in the near term, if not immediately. More noteworthy than the more conventional 3D graphics features Turing added is what it didn't subtract from the company's previous compute/artificial intelligence (AI)–focused GPU, Volta. With Turing, NVIDIA architects not only didn't denude out Volta's Tensor Cores, they improved on them — and doubled down on the pursuit of real-time rendering by boosting ray-trace-specific acceleration.

    Tensor Cores accelerated AI for ray-tracing — and now they speed conventional 3D raster graphics to boot. Volta's most noteworthy advancement was the inclusion of Tensor Cores, novel hardware engines — of significant incremental chip cost (i.e. transistors/silicon area) — to accelerate processing of deep neural networks (DNNs), the lifeblood of machine learning applications. Now, given Volta's primary focus on high-performance computing rather than 3D graphics, the altenative to elect on the silicon cost of Tensor Cores was certainly novel, but not particularly contentious.

    But unlike Volta and its compute focus, Turing is a graphics-first architecture, so NVIDIA's determination to withhold Tensor Cores in Turing raises a very pertinent question: Why would the company dedicate significant cost in a graphics-focused GPU to a feature that doesn't directly capitalize graphics? Well, the answer is most inspiring and fortunate: That ragged premise is no longer true, and NVIDIA is now finding compelling ways to leverage machine learning to ameliorate the property and performance of 3D imagery.

    As discussed in detail in a previous column, "What Does NVIDIA's Ray Tracing news subsist primary for the CAD Market?" NVIDIA figured out a course to leverage deep learning to significantly ameliorate the performance of ray-traced 3D rendering. Specifically, RTX software exploits Tensor Core hardware incorporated in a DNN in the ray-tracer to accelerate image "convergence" by decreasing the computational load in the latter stages of rendering. Once the image converges into something it can recognize, AI fills in remaining rays/pixels, intelligently de-noising the image and wrapping up the time-consuming rendering process far faster than is possible via exhaustive, full-resolution ray processing.

    RTX technology on Volta (right side) accelerates ray-tracing through machine learning. (Source: NVIDIA)RTX technology (right side) accelerates ray-tracing through AI-accelerated de-noising, compared with the same number of rays without de-noising (left).  (Source: NVIDIA)

    No doubt enthused by the successful synergy of machine learning and graphics with ray-trace processing, NVIDIA researchers began exploring other ways to extract more visual processing goodness out of its GPUs' AI prowess. Extending on the consume of DNNs for ray-trace de-noising, NVIDIA unveiled NGX technology, comprised of an expanded set of DNN-driven image-enhancement features.

    The most apropos and compelling sample using Turing/NGX to enhance conventional 3D graphics is deep Learning Super Sampling (DLSS). Essentially, DLSS benefits from a Tensor Core–accelerated DNN that substitutes the habitual brute-force pixel super-sampling with smart choices based on the scene geometry, and based both on one frame instance and interframe temporal changes. The capitalize is that property improves at the same performance level, or likely more inspiring for most applications (because resolution-dependent property is pretty darn generous at this point), performance increases significantly at the same property level. I beget no doubt NVIDIA sees NGX today as anything but a fixed set of features, but rather an evolving and expanding toolbox of DNNs that can further harness machine learning for the capitalize of NVIDIA's traditional visual markets as time goes on.

    AI-enabled DLSS anti-aliasing: There’s  worthy value in any GPU feature that can deliver the same  property in fewer cycles. (Source: NVIDIA)AI-enabled DLSS anti-aliasing: There's worthy value in any GPU feature that can deliver the same property in fewer cycles. (Source: NVIDIA)

    And NVIDIA Doubles Down with RT Cores

    Not only did NVIDIA preserve those Tensor Cores when creating Turing, it took the further step of adding multiple instances (one per SM) of an entirely novel core design: the RT Core. Specifically, the RT Core takes on a captious ray-tracing computing task, one that when executing on previous GPUs' SMs proved cumbersome, inefficient, and time-intensive. Determining whether a ray (shot from a viewport out into the scene) actually intersects an demur (and which triangle on that object's surface) is one of those tasks that a traditional raster-based 3D shader wasn't designed to do, and therefore doesn't execute particularly well. With Turing, that job is now left to the RT Cores, freeing up the SMs to spend cycles instead on the 3D shader processing they're more adept at executing.

    Turing’s Streaming Multiprocessor with RT Core. (Source: NVIDIA)Turing's Streaming Multiprocessor with RT Core. (Source: NVIDIA)

    What's the internal micro-architecture of the RT Core notice like? Well, NVIDIA hasn't exposed the guts, but given its chore — a lot of 3D geometry processing — there's minute doubt some high-performance vector and matrix floating-point units shape its foundation. What NVIDIA has disclosed is the performance of the RT Core: 10 GigaRays/second. Now, in absolute terms, that's a difficult number to assess — relish triangles/second in the rasterization world — as it everyone depends on the workload of each ray measured. The more relevant, apples-to-apples comparison is that rate relative to Pascal's 1.1 GigaRays/second, presumably of the same workload per ray. Given that, Turing is packing a 10X performance improvement processing a crucial and demanding portion of the ray-tracing pipeline.

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